心脑血管病防治2024，Vol.24Issue(3)：15-18,22,5.DOI:10.3969/j.issn.1009-816x.2024.03.004
血清前蛋白转化酶枯草溶菌素9与急性心肌梗死患者经皮冠状动脉介入治疗预后不良的相关性
Correlation between serum proprotein convertase subtilisin/kexin type 9 and poor prognosis of patients with acute myocardial infarction after percutaneous coronary intervention
摘要
Abstract
Objective To explore the relationship between serum proprotein convertase subtilisin/kexin type 9(PCSK9)and poor prognosis of patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods A total of 207 patients with AMI who underwent PCI in Handan Central Hospital from June 2018 to December 2021 were selected and divided into the good prognosis group(171 cases)and the poor prognosis group(36 cases)after 1-year follow-up.Clinical data of patients were collected,serum PCSK9 and cardiac troponin I(cTnI)levels were mearsured before PCI,1 day after PCI,3 days after PCI,and 5 days after PCI.Clinical data,serum PCSK9 and cTnI levels at different time points were compared between the good prognosis group and the poor prognosis group.Logistic regression analysis was performed to identify influencing factors for poor prognosis after PCI in patients with AMI.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of serum PCSK9 levels at 3 and 5 days after PCI for poor prognosis in patients with AMI.Results The proportion of hypertension history,levels of low density lipoprotein-cholesterol and triglyceride,and serum levels of PCSK9 and cTnI at 3 and 5 days after PCI in the poor prognosis group were significantly higher than those in the good prognosis group(t/χ2=6.471,14.615,10.698,10.024,30.088,19.299,13.148;P＜0.05).History of hypertension and high serum PCSK9 level at 3 and 5 days after PCI were independent risk factors for the poor prognosis in patients with AMI after PCI[OR(95%CI)=2.614(1.382-4.943),2.847(1.782-4.548),2.646(1.487-4.708);P＜0.01].The area under the curve(AUC)based on the serum PCSK9 level at 3 days after PCI in predicting the poor prognosis of patients with AMI after PCI was 0.871,with a cut-off value of 29.34 ng/mL,sensitivity of 74.71%,and specificity of 81.52%.The AUC based on the serum PCSK9 level at 5 days after PCI in predicting the poor prognosis of patients with AMI after PCI was 0.911,with a cut-off value of 20.12 ng/mL,sensitivity of 85.72%,and specificity of 81.93%.Conclusion Monitoring PCSK9 level at 3 and 5 days after PCI has a high predictive value for poor prognosis of patients with AMI.关键词
前蛋白转化酶枯草溶菌素9/急性心肌梗死/经皮冠状动脉介入治疗/预后Key words
Proprotein convertase subtilisin/kexin type 9/Acute myocardial infarction/Percutaneous coronary intervention/Prognosis引用本文复制引用
宋朝国,刘健,贺宝臣,杨伟光..血清前蛋白转化酶枯草溶菌素9与急性心肌梗死患者经皮冠状动脉介入治疗预后不良的相关性[J].心脑血管病防治,2024,24(3):15-18,22,5.基金项目
河北省医学科学研究课题计划(20200474) （20200474）
