高分贝音乐与心血管疾病因果关系的孟德尔随机化研究OACSTPCD

Objective This study employed a two-sample Mendelian randomization approach to investigate the causal relationship between high-decibel music exposure and six cardiovascular diseases.Methods From the whole-genome association study database,single nucleotide polymorphisms related to high-decibel music,hypertension,ischemic stroke,coronary artery atherosclerosis,myocardial infarction,atrial fibrillation,and heart failure,were screened as genetic instrumental variables.Three Mendelian randomization analysis methods,including inverse variance-weighted method,MR-Egger method,and weighted median method,were utilized to evaluate the causal relationship between high-decibel music and cardiovascular diseases.Sensitivity analyses were conducted using Cochran's Q test,MR-Egger regression,MR-PRESSO analysis,and leave-one-out method.Results The inverse variance-weighted method indicated a positive correlation between high-decibel music and ischemic stroke[OR(95%CI)=1.424(1.061-1.911),P＜0.05]as well as coronary artery atherosclerosis[OR(95%CI)=1.428(1.065-1.915),P＜0.05],consistent with the results of the weighted median method.Mendelian randomization analysis revealed no association between high-decibel music and hypertension,myocardial infarction,atrial fibrillation,and heart failure(P＞0.05).Sensitivity analysis demonstrated no bias in the study results,and instrumental variables exhibited no heterogeneity.Conclusion There is a positive causal relationship between high-decibel music and ischemic stroke,as well as coronary artery atherosclerosis.Further research is needed to explore the causal effects of high-decibel music on other cardiovascular diseases.