老年急性心肌梗死伴心力衰竭患者血清中Kruppel样因子15、微小核糖核酸128-3p表达与心功能的关系OACSTPCD

Objective To investigate the relationship between serum Kruppel-like factor 15(KLF15)and micro ribonucleic acid 128-3p(miR-128-3p)serum expression levels and the cardiac function in elderly patients with acute myocardial infarction(AMI)and heart failure.Methods From August 2020 to August 2021,112 elderly patients with AMI and heart failure admitted to Xiangzhou District People's Hospital,Xiangyang City were included as the AMI with heart failure group,and 120 patients with simple AMI with matched general data during the same period were included as the AMI group.All patients underwent echocardiography to detect cardiac function and record left ventricular end-systolic diameter(LVESd),left ventricular end-diastolic diameter(LVEDd),and left ventricular ejection fraction(LVEF).The levels of brain natriuretic peptide(BNP),creatine kinase isoenzyme(CK-MB),cardiac troponin I(cTnI),KLF15 and miR-128-3p in the serum of the patients were determined.Pearson correlation analysis was used to analyze the correlation between serum KLF15,miR-128-3p expression levels and the levels of BNP,CK-MB,cTnI,LVESd,LVEDd,and LVEF in elderly patients with AMI and heart failure,and to analyze the correlation between serum KLF15 and miR-128-3p.Results Compared with the AMI group,AMI with heart failure group had higher expression levels of miR-128-3p,BNP,CK-MB,cTnI,LVESd and LVEDd(t/Z=38.306,5.865,7.997,20.575,16.037,17.368;P<0.05),and lower levels of LVEF and KLF15(t=24.072,47.301;P<0.05).The level of serum mir-128-3p in AMI patients with heart failure increased with the increase of cardiac function grading(F=322.866,P<0.05),while the level of KLF15 decreased(F=221.228,P<0.05).The expression level of serum miR-128-3p in elderly patients with AMI and heart failure was positively correlated with BNP,CK-MB and cTnI(r=0.667,0.525,0.617;P<0.05),and negatively correlated with LVEF(r=-0.537,P<0.05).The expression level of serum KLF15 was negatively correlated with BNP,CK-MB,cTnI and LVEDd(r=-0.531,-0.574,-0.562,-0.416;P<0.05),and positively correlated with LVEF(r=0.624,P<0.05).The TargetScan website predicted that miR-128-3p had a target binding site for KLF15.Pearson analysis showed that serum miR-128-3p was negatively correlated with KLF15 in elderly patients with AMI and heart failure(r=-0.853,P<0.05).Conclusion Serum KLF15 level is decreased and miR-128-3p level is increased in elderly patients with AMI and heart failure,and both are correlated with patients'cardiac function indexes,which can be used as biomarkers for judging the cardiac function of patients with AMI and heart failure.