溶栓介入联合治疗对急性心肌梗死患者术后血清cTnI、BNP、PCT水平及生存质量的影响OACSTPCD

Objective To investigate the effect of thrombolysis combined with interventional therapy in patients with acute myocardial infarction(AMI).Methods Ninety-four patients with AMI admitted to the First Central Hospital of Baoding City from January 2019 to October 2021 were randomly divided into two groups,with 47 patients in each group.The percutaneous coronary intervention(PCI)group underwent PCI surgery within 90 minutes after admission,while the thrombolysis group received thrombolysis intervention first and then underwent PCI surgery.Infarct-related vascular recanalization,ST segment depression and stent implantation were recorded for both groups.Cardiac function indexes,troponin I,brain natriuretic peptide,procalcitonin levels and complications were compared between the two groups.The prognosis and quality of life were evaluated during a 6-month follow-up after discharge.Results The proportion of patients with infarct-related vascular recanalization and ST segment depression in the thrombolysis group were higher than those in the PCI group,with statistical significance(χ2=7.231,21.226;P<0.05).The left ventricular end-systolic diameter,left ventricular end-diastolic diameter,and left ventricular short-axis shortening fraction in the thrombolysis group were lower than those in the PCI group,while the left ventricular ejection fraction was higher than that in the PCI group,with statistical significance(t=2.621,4.324,9.020,5.556;P<0.05).The post-treatment levels of troponin I,brain natriuretic peptide and procalcitonin in the thrombolysis group were lower than those in the PCI group,with statistically significant differences(t=5.966,12.546,6.903;P<0.05).There was no significant difference in the incidence of complications between the thrombolysis group and the PCI group(χ2=0.224,P>0.05).In the 6-month follow-up,the rates of recurrent infarction,recurrent angina pectoris and re-hospitalization in the thrombolysis group were lower than those in the PCI group,with statistically significant differences(χ2=4.178,4.065,3.887;P<0.05).The score of post-treatment health status questionnaire in the thrombolytic group was higher than that in the PCI group,and the difference was statistically significant(t=7.899,P<0.05).Conclusion The combination of thrombolysis and intervention therapy in AMI patients can improve the therapeutic effect,prognosis,and quality of life of patients.