高血压脑出血患者血浆中脂蛋白相关磷脂酶A2、缺氧诱导因子1α表达水平与预后的关系OACSTPCD
Relationship between plasma expression levels of lipoprotein-associated phospholipase A2 and hypoxia-inducible factor 1α and the prognosis in patients with hypertensive intracerebral hemorrhage
目的 观察高血压脑出血患者血浆中脂蛋白相关磷脂酶A2(Lp-PLA2)、缺氧诱导因子1α(HIF-1α)的表达水平及其与患者预后的关系.方法 选取2019年4月至2021年3月间在梁平区人民医院治疗的高血压脑出血患者65例作为观察组,同时选取同期在本院进行治疗的未发生脑出血的高血压患者 68 例作为对照组,检测所有患者血浆中Lp-PLA2、HIF-1α表达水平,并分析Lp-PLA2、HIF-1α与高血压脑出血患者预后的关系.根据患者临床资料分析影响高血压脑出血患者预后的因素;多因素Logistic回归分析高血压脑出血患者预后的影响因素.结果 观察组患者的血浆中Lp-PLA2、HIF-1α表达水平高于对照组,预后不良组患者血浆中Lp-PLA2、HIF-1α表达水平高于预后良好组,差异均有统计学意义(t=15.314、14.580、4.086、3.495,均P<0.05).预后不良组高血压脑出血患者年龄、高血压病程、发病至入院时间、初始血肿量及合并糖尿病与预后良好组比较,差异均有统计学意义(χ2/t=2.480、2.580、2.307、5.101、5.532,均P<0.05).多因素Logistic回归分析显示患者血浆中Lp-PLA2、HIF-1α高表达水平是高血压脑出血的影响因素(OR=2.498、2.635,均P<0.05).结论 高血压脑出血患者血浆中Lp-PLA2、HIF-1α表达水平均显著升高,是患者预后不良的影响因素.
Objective To observe the expression levels of lipoprotein-associated phospholipase A2(Lp-PLA2)and hypoxia-inducible factor 1α(HIF-1α)in the plasma of patients with hypertensive cerebral hemorrhage and their relationship with the prognosis.Methods Sixty-five patients with hypertensive cerebral hemorrhage treated in Liangping District People's Hospital from April 2019 to March 2021 were selected as the observation group.Sixty-eight hypertensive patients without cerebral hemorrhage treated in our hospital in the same period were selected as the control group.The expression levels of Lp-PLA2 and HIF-1α in patients'plasma were detected,and the relationship between Lp-PLA2,HIF-1α and the prognosis of patients with hypertensive intracerebral hemorrhage was analyzed.The factors affecting the prognosis of patients with hypertensive intracerebral hemorrhage were analyzed based on patients'clinical data,and multivariate Logistic regression was used to analyze risk factors affecting the prognosis of patients with hypertensive intracerebral hemorrhage.Results The expression levels of Lp-PLA2 and HIF-1α in the plasma of patients in the observation group were higher than those in the control group,and the expression levels of Lp-PLA2 and HIF-1α in the plasma of patients in the poor prognosis group were higher than those in the good prognosis group,the differences were all statistically significant(t=15.314,14.580,4.086,3.495;all P<0.05).There were statistically significant differences between the poor prognosis group and the good prognosis group in terms of age,duration of hypertension,time from onset to hospital admission,initial hematoma volume and concomitant diabetes(χ2/t=2.480,2.580,2.307,5.101,5.532;all P<0.05).Multivariate Logistic regression analysis showed that high expression levels of Lp-PLA2 and HIF-1α in the plasma of patients were influencing factors affecting hypertensive intracerebral hemorrhage(OR=2.498,2.635;all P<0.05).Conclusion The expression levels of Lp-PLA2 and HIF-1α in the plasma of patients with hypertensive intracerebral hemorrhage are significantly increased,which are influencing factors for the poor prognosis of these patients.
牟连生;邹文凡;杜德伟;张令
405200 重庆市梁平区人民医院神经外科
高血压脑出血脂蛋白相关磷脂酶A2缺氧诱导因子 1α
HypertensionCerebral hemorrhageLipoprotein-associated phospholipase A2Hypoxia-inducible factor 1α
《心脑血管病防治》 2024 (004)
28-31 / 4
重庆市医学科研计划项目(20142207)
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