中国渔业质量与标准2024，Vol.14Issue(2)：1-6,6.DOI:10.3969/j.issn.2095-1833.2024.02.001
硫酸新霉素在黑脊倒刺鲃(Spinibarbus caldwelli)体内的残留消除规律研究
Studies on the residues and degradation rules of neomycin sulfate in Spinibarbus caldwelli
摘要
Abstract
At a water temperature of(23±2)℃,Spinibarbus caldwelli was treated with a single oral administration of neomycin sulfate at a dosage of 60 mg/kg body weight.The concentration of neomycin sulfate in the muscle,liver,and kidney of Spinibarbus caldwelli was determined using HPLC-MS/MS,and the residues and degradation patterns of neomycin sulfate in Spinibarbus caldwelli were studied.The results revealed that after a single dose of oral adminis-tration of neomycin sulfate,the elimination half-life T1/2ke of neomycin sulfate in the muscle,liver,and kidney of Spinibarbus caldwelli were 44.62 h,248.50 h,and 616.90 h,respectively.This indicated that neomycin sulfate was eliminated most rapidly in the muscle,followed by the liver,and slowest in the kidney.Muscle was used as the target tissue for residual detection.According to the current National Food Safety Standard-Maximum Residue Limit of Veterinary Drugs in Food(GB 31650-2019),the maximum residue limit of neomycin sulfate in all food animal mus-cles is set at 500 μg/kg.Therefore,it is recommended to refrain from consuming Spinibarbus caldwelli until at least 10 d have passed under the experimental conditions to ensure safety.[Chinese Fishery Quality and Standards,2024,14(2):01-06]关键词
黑脊倒刺鲃/硫酸新霉素/药代动力学/残留/消除规律Key words
Spinibarbus caldwelli/neomycin sulfate/pharmacokinetics/residues/degradation rules分类
农业科技引用本文复制引用
林丽聪,林煜,钟全福,卓玉琛,樊海平,吴斌,黄美玲..硫酸新霉素在黑脊倒刺鲃(Spinibarbus caldwelli)体内的残留消除规律研究[J].中国渔业质量与标准,2024,14(2):1-6,6.基金项目
福建省科技计划项目—省属公益类科研院所基本科研专项(2021R1014001) （2021R1014001）
