中国渔业质量与标准2024，Vol.14Issue(2)：7-13,7.DOI:10.3969/j.issn.2095-1833.2024.02.002
超高效液相色谱-串联质谱法测定水体中磺胺类药物残留量方法验证
Determination of Sulfonamides Residues in water by ultra performance liquid chromatography-tandem mass spectrometry
摘要
Abstract
Standard method validation is an important part of the quality management process in inspection and testing laboratories,and is the foundation for ensuring the accuracy of inspection and testing data.In this study,a method for determination of sulfonamides residues in water by UPLC-MS/MS was established.Verify the method from standard curve,linear range,quantification limit,precision,and method recovery rate.And the key experimental points of this method were analyzed and optimized.17 kinds of sulfonamides had good linearity within the concentration range of 5.0～50.0 ng/mL.The correlation coefficient of calibration curve was more than0.997.The detection limit of this method was 0.038 ng/mL.The average recovery rates of three spiked levels ranged from 74.6%to 105.6%,and the relative standard deviations were 0.89%～12.89%.This method was applied to detect the residues of sulfonamide drugs in water samples and aquaculture pond water samples in Jiading District,Shanghai.The establishment of this method can provide technical basis for monitoring the residues of sulfonamide drugs in rivers and aquaculture water.[Chinese Fishery Quality and Standards,2024,14(2):07-13]关键词
水体/磺胺类抗生素/超高效液相色谱—串联质谱/残留检测Key words
water/sulfonamides/ultra performance liquid chromatography-tandem mass spectrometry/residual de-tection分类
化学化工引用本文复制引用
余海芬,徐桦,陶军,吴真善,包蔚,朱晓芸..超高效液相色谱-串联质谱法测定水体中磺胺类药物残留量方法验证[J].中国渔业质量与标准,2024,14(2):7-13,7.基金项目
上海市嘉定区自然科学研究课题(JDKW-2021-0010) （JDKW-2021-0010）
