遵义医科大学学报2024，Vol.47Issue(5)：438-441,4.
高产乙醇肺炎克雷伯菌的危害及感染应对策略
Harm and response strategies of high-alcohol-producing Klebsiella pneumoniae
摘要
Abstract
High-alcohol-producing Klebsiella pneumoniae(HiAlc Kpn)can produce large amounts of endoge-nous alcohol in the intestines of patients,which is a new cause of nonalcoholic fatty liver disease(NAFLD)and seriously endangers human health.Antibiotic treatment is the main way to deal with bacterial infections,but the antibiotic resistance is becoming increasingly serious in K.pneumoniae,and antibiotics often disrupt the balance of human gut microbiota.Phage therapy is expected to treat NAFLD by targeted killing of HiAlc Kpn without de-stroying healthy intestinal microbiota.At the same time,we should actively search for targets that affect the alco-hol-producing capacity of HiAlc Kpn,so as to provide theoretical basis for the development of anti-virulence drugs.This paper mainly describes the harmfulness of HiAlc Kpn and puts forward some strategies to treat HiAlc Kpn infection.关键词
肺炎克雷伯菌/乙醇/抗生素/噬菌体Key words
Klebsiella pneumoniae/alcohol/antibiotic/phage分类
医药卫生引用本文复制引用
袁静..高产乙醇肺炎克雷伯菌的危害及感染应对策略[J].遵义医科大学学报,2024,47(5):438-441,4.基金项目
国家自然科学基金重点项目(NO:82130065). （NO:82130065）
