遵义医科大学学报2024，Vol.47Issue(5)：454-460,7.
一株多重耐药准肺炎克雷伯菌的基因组和耐药基因分析
Genomic analysis and antimicrobiol resistant genes of a Klebsiella quasipneu-moniae subsp.similipneumoniae stain
摘要
Abstract
Objective In this study,we aimed to study the complete genome and multidrug resistance character-istics of Klebsiella quasipneumoniaen subsp.similipneumoniae isolated from neonatal feces.Methods E-test anti-biotic sensitivity detection,whole genome sequencing technology and bioinformation analysis were used.Results This strain possessed multidrug resistance and was resistant to the antibiotics commonly used in clinic,including amoxicillin clavulanate,ceftazidime,cefazolin,cefuroxime,ceftriazmecefoperazone,and meropenem.Whole ge-nome sequencing suggests that this strain carries two plasmids,which are highly similar to the previously reported plasmids IncFII and IncX3.Moreover,the two plasmids carry important carbapenem resistance genes,namely blaTEM-1D,blaNDM-1,blaCTX-M-15and blaSHV-12.At the same time,the chromosome DNA also carries some important drug resistance genes,such as blaOKP-B-2.These resistance genes can explain the occurrence of the resistance phenotypes and suggest that these resistance genes have a certain risk of transmission along with the plasmid.Conclusion This study suggests that we should distinguish between Klebsiella quasipneumoniae and Klebsiella pneumoniae and focus on the infection and drug resistance in the future.关键词
准肺炎克雷伯菌/耐药/基因组/质粒Key words
Klebsiella quasipneumoniae subsp.similipneumoniae/multidrug resistance/genomic analysis/plas-mid分类
基础医学引用本文复制引用
崔晶花,于子惠,孔一鸣,丁赞博,袁静..一株多重耐药准肺炎克雷伯菌的基因组和耐药基因分析[J].遵义医科大学学报,2024,47(5):454-460,7.基金项目
国家自然科学基金面上项目(NO:82272352). （NO:82272352）
