遵义医科大学学报2024，Vol.47Issue(5)：495-501,7.
遵义地区肺结核耐药特征及利福平耐药影响因素分析
Analysis of drug resistance characteristics of pulmonary tuberculosis in Zunyi city and influential factors of rifampicin resistance
摘要
Abstract
Objective Drug-resistant tuberculosis(DR-TB)is an important obstacle to achieving the goal of ending the global TB epidemic by 2035.China is a country with high prevalence of multidrag-resistant tubercu-losis(MDR-TB)and Rifampicin-resistant tuberculosis(RR-TB)in which Guizhou province is one of the regions with a serious tuberculosis epidemic.This study analyzed the epidemiological characteristics of drug-resistant tu-berculosis in Zunyi City to explore its epidemic trend.Methods Clinical information and sputum or bronchoalve-olar lavage fluid samples of tuberculosis patients from the Affiliated Hospital of Zunyi Medical University from 2016 to 2018 were collected.Mycobacterium tuberculosis was isolated and cultured using Lowenstein-Jensen(L-J)medium,and its sensitivity to four first-line and six second-line anti-tuberculosis drugs was detected by tradi-tional drug sensitivity test.The prevalence trend of drug-resistant TB from 2008 to 2018 was retrospectively com-pared,and the related factors of rifampicin resistance were analyzed.Results Among the 1 063 patients with tu-berculosis,the incidence of male patients was significantly higher than that of female patients,with the age group of mainly covered 16-79 years old.Rifampicin-resistant tuberculosis(RR-TB)accounted for 13.2％(140/1 063),and Multidrug-resistant tuberculosis(MDR-TB)accounted for 11.5％(122/1 063).Pre-exten-sive drug resistance tuberculosis(pre-XDR-TB)accounted for 15.1％(37/245)of randomized second-line drug-sensitive cases.Age group,treatment history and regional distribution were the factors influencing rifampi-cin resistance.Conclusion Although the epidemic situation of drug-resistant TB in Guizhou Province has a remis-sion trend,the incidence of MDR/RR-TB is still at a high level,and the level of surveillance and hierarchical diagnosis and treatment of drug-resistant TB in Guizhou province should be strengthened.关键词
结核分枝杆菌/耐药结核病/耐药模式/流行病学Key words
mycobacterium tuberculosis/drug-resistant tuberculosis/drug resistance pattern/epidemiology分类
医药卫生引用本文复制引用
娄思玉,吴霞,杨丹,付雪峰,李青,彭章丽,陈玲..遵义地区肺结核耐药特征及利福平耐药影响因素分析[J].遵义医科大学学报,2024,47(5):495-501,7.基金项目
国家自然科学基金地区基金资助项目(NO:81760003 （）
81960004) （）
遵义市科技计划项目[NO:遵义市科合HZ字(2021)86]. （2021）
