首页|期刊导航|Neural Regeneration Research|Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

Yanli Zhang Tian Li Jie Miao Zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting Li Qiang Su Junhong Guo

Neural Regeneration Research2025，Vol.20Issue(2)：P.533-547,15.

Neural Regeneration Research2025，Vol.20Issue(2)：P.533-547,15.DOI:10.4103/NRR.NRR-D-23-01525

Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

Yanli Zhang ¹Tian Li ²Jie Miao ³Zhina Zhang ³Mingxuan Yang ³Zhuoran Wang ³Bo Yang ⁴Jiawei Zhang ³Haiting Li ³Qiang Su ⁵Junhong Guo³

作者信息

1. Department of Neurology,First Hospital of Shanxi Medical University,Taiyuan,Shanxi Province,China Department of Neurology,Sixth Hospital of Shanxi Medical University(General Hospital of Tisco),Taiyuan,Shanxi Province,China
2. Department of Physiology,Key Laboratory of Cellular Physiology,Ministry of Education,Shanxi Medical University,Taiyuan,Shanxi Province,China
3. Department of Neurology,First Hospital of Shanxi Medical University,Taiyuan,Shanxi Province,China
4. Department of Hernia and Abdominal Wall Surgery,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,Third Hospital of Shanxi Medical University,Taiyuan,Shanxi Province,China
5. Department of Physiology,Key Laboratory of Cellular Physiology,Ministry of Education,Shanxi Medical University,Taiyuan,Shanxi Province,China Department of Laboratory Medicine of Fenyang College,Shanxi Medical University,Fenyang,Shanxi Province,China
折叠

摘要

关键词

Alzheimer’s disease/amyloid-β/APP/PS1 mice/cerebrovascular endothelial cells/cognitive deficits/gamma-glutamyl transferase 5/neurovascular unit/nuclear factor‐kappa B/synaptic plasticity/β-site APP cleaving enzyme 1

分类

医药卫生

引用本文复制引用

Yanli Zhang,Tian Li,Jie Miao,Zhina Zhang,Mingxuan Yang,Zhuoran Wang,Bo Yang,Jiawei Zhang,Haiting Li,Qiang Su,Junhong Guo..Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice[J].Neural Regeneration Research,2025,20(2):P.533-547,15.

基金项目

supported by STI2030-Major Projects,No.2021ZD 0201801(to JG) （to JG）

Shanxi Province Basic Research Program,No.20210302123429(to QS). （to QS）

Neural Regeneration Research

ISSN：1673-5374

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