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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan Liu Jie Gao You Yin

Neural Regeneration Research2025，Vol.20Issue(2)：P.424-439,16.

Neural Regeneration Research2025，Vol.20Issue(2)：P.424-439,16.DOI:10.4103/NRR.NRR-D-23-01736

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

Mengqi Hao ¹Jianjian Chu ²Tinglin Zhang ³Tong Yin ²Yuankai Gu ²Wendanqi Liang ¹Wenbo Ji ²Jianhua Zhuang ²Yan Liu ⁴Jie Gao ³You Yin⁵

作者信息

1. Department of Neurology,Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital),Shanghai,China School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai,China
2. Department of Neurology,Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital),Shanghai,China
3. Changhai Clinical Research Unit,Shanghai Changhai Hospital,Naval Medical University,Shanghai,China
4. Department of Clinical Pharmacy,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China
5. Department of Neurology,Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital),Shanghai,China Department of Neurology,Shanghai East Hospital,School of Medicine,Tongji University,Shanghai,China
折叠

摘要

关键词

Alzheimer’s disease/autophagy dysfunction/lysosomal acidification/lysosomal system/nanomaterials/neurodegenerative diseases

分类

医药卫生

引用本文复制引用

Mengqi Hao,Jianjian Chu,Tinglin Zhang,Tong Yin,Yuankai Gu,Wendanqi Liang,Wenbo Ji,Jianhua Zhuang,Yan Liu,Jie Gao,You Yin..Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease[J].Neural Regeneration Research,2025,20(2):P.424-439,16.

基金项目

supported by the Natural Science Foundation of Shanghai,No.22ZR147750 （）

Science and Technology Innovation Action Plan of Shanghai Science and Technology Commission,No.23Y11906600 （）

Shanghai Changzheng Hospital Innovative Clinical Research Project,No.2020YLCYJ-Y02(all to YY). （all to YY）

Neural Regeneration Research

ISSN：1673-5374

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