癌变·畸变·突变2024，Vol.36Issue(3)：172-178,7.DOI:10.3969/j.issn.1004-616x.2024.03.002
不同粒径和来源大气颗粒物暴露与孕妇子痫前期发生风险的关联研究
A retrospective analysis on the impact of size-and source-specific ambient particles on preeclampsia
摘要
Abstract
OBJECTIVE:This study aimed to examine the impact of size-segregated and source-specific ambient particles on preeclampsia risk.METHODS:This study was conducted based on the antenatal examination records from Maternal and Child Health Hospital from 2014-2018 in Beijing,China.Particle number concentrations(PNC)of particles in size fractions of 5-560 nm and meteorological data in this study area were collected.The sources of PNC5-560 were apportioned using the positive matrix factorization method.Logistic regression was used to analyze associations between maternal exposure to ambient particles and preeclampsia risk.RESULTS:Maternal exposure to particles in size fractions of 5-200 nm during preconception and early pregnancy was associated with increased risk of preeclampsia.Per an interquartile range(IQR)increment in PNC25-100 and PNC100-200 exposure during preconception,the excess risks of PE increased by 36%[OR(odd ratio)=1.36,95%CI(1.04,1.76)]and 40%[OR=1.40,95%CI(1.12,1.76)],respectively.Per an IQR increment in PNC5-25 and PNC100-200 exposure during early pregnancy,the excess risks of PE increased by 46%[OR=1.46,95%CI(1.15,1.83)]and 40%[OR=1.40,95%CI(1.08,1.82)],respectively.Maternal exposure to nucleation and gasoline vehicle emissions during preconception and early pregnancy was associated with the risk of preeclampsia.CONCLUSION:Maternal exposure to traffic-related ultrafine particles during preconception and early pregnancy may increase the risk of preeclampsia.关键词
大气颗粒物/超细颗粒物/源解析/子痫前期Key words
ambient particle/ultrafine particles/source apportionment/preeclampsia分类
医药卫生引用本文复制引用
李梦瑶,刘海燕,宋晓明,杨英,黄薇,邹晓璇,徐洪兵,赵银珠,何兴侯,杨海珊,张彬,王硕,单旭阳..不同粒径和来源大气颗粒物暴露与孕妇子痫前期发生风险的关联研究[J].癌变·畸变·突变,2024,36(3):172-178,7.基金项目
北京市自然科学基金(7222246) （7222246）
