北京中医药大学学报2024，Vol.47Issue(5)：699-703,5.DOI:10.3969/j.issn.1006-2157.2024.05.014
基于中医体质学基本原理探讨中性粒细胞胞外诱捕网与支气管哮喘发病的内涵
A new connotation of neutrophil extracellular traps and bronchial asthma pathogenesis based on the basic principles of traditional Chinese medicine constitution
摘要
Abstract
Bronchial asthma(asthma)is a common clinical respiratory disease mediated by multiple cells and components,and neutrophils,as one of the classic innate immune cells,play an important role in the pathogenesis of asthma.In the inflammatory state,neutrophils release neutrophils extracellular trap(NET)into the periphery through the NETosis procedure.Although NET is a beneficial antibacterial defense structure,its excessive accumulation can trigger different response mechanisms that can also adversely affect the lungs and exacerbate asthma.Based on the basic principles of traditional Chinese medicine constitution,exploring the important role of NET in the pathogenesis of asthma,it holds that the life process theory body-spirit composition theory,endowment inheritance theory,and environmental constraint theory are related to the gradual formation of NET and different stimuli affect the heterogeneity of NET,thereby mediating different biological effects during the onset of asthma.Targeting NET and/or its components may become a new treatment strategy on asthma.关键词
中医体质/支气管哮喘/中性粒细胞/中性粒细胞胞外诱捕网Key words
traditional Chinese medicine constitution/bronchial asthma/neutrophils/neutrophil extracellular traps分类
医药卫生引用本文复制引用
宗玉涵,王曼婷,杨帆,孔靖玮,王济..基于中医体质学基本原理探讨中性粒细胞胞外诱捕网与支气管哮喘发病的内涵[J].北京中医药大学学报,2024,47(5):699-703,5.基金项目
国家自然科学基金面上项目(No.81973715,No.82174243) （No.81973715,No.82174243）
国家中医药管理局中医药创新团队及人才支持计划项目(No.ZYYCXTD-C-202001) National Natural Science Foundation of China(Nos.81973715 and 82174243) （No.ZYYCXTD-C-202001）
