现代中医临床2024，Vol.31Issue(3)：1-6,20,7.DOI:10.3969/j.issn.2095-6606.2024.03.001
甘草油加味治疗糖尿病足游离皮片植皮术后创面的临床观察
Clinical observation of supplemented licorice oil therapy in the treatment of postoperative wounds after free skin grafting of diabetic foot
摘要
Abstract
Objective To evaluate the clinical efficacy of supplemented licorice oil therapy in the treatment of postoperative wounds after free skin grafting of diabetic foot.Methods A total of 60 patients after free skin grafting for diabetic foot(DF)were randomly divided into a treatment group(supplemented licorice oil therapy group,n=40)and a control group(licorice oil therapy group,n=20)in a 2∶1 ratio.The patients underwent debridement or toe amputation as needed,followed by free skin grafting under conditions of adequate local wound bed preparation.The two groups received treatment with single-layer gauze strips soaked with supplemented licorice oil and regular licorice oil,respectively,on the third postoperative day,followed by covering with sterile dry gauze.Dressing changes were performed daily.Each course of treatment lasted for one month,with a total of two consecutive courses.Clinical efficacy,wound size,wound score(main symptom:pain score;secondary symptoms including skin color,swelling,and temperature),serum levels of C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),fibrinogen(FIB),and wound matrix metalloproteinases(MMPs)MMP-2 and MMP-9 concentrations were observed.Results After treatment,both groups showed a reduction in wound size compared to before treatment,with a more significant reduction observed in the treatment group(P<0.05).After treatment,both groups showed a decrease in wound score compared to before treatment,with a more significant decrease observed in the treatment group(P<0.05).After treatment,both groups showed a decrease in serum CRP and FIB levels compared to before treatment,with a more significant decrease observed in the treatment group(P<0.05).There were no significant differences in serum ESR levels between the two groups after treatment(P>0.05).After treatment,both groups showed a decrease in wound MMP-2 and MMP-9 concentrations compared to before treatment,with a more significant decrease observed in the treatment group(P<0.05).The total effective rate of the treatment group was 92.5%(37/40),which was significantly higher than that of the control group(85.0%,17/20)(P<0.05).Conclusion Supplemented licorice oil therapy demonstrates superior clinical efficacy in wound repair following free skin grafting for diabetic foot.关键词
糖尿病足/游离皮片植皮术糖尿病足植皮术后/创面/甘草油加味/临床观察Key words
diabetic foot/free skin grafting/postoperative care for skin grafting in DF patients/wound/supplemented licorice oil/clinical observation分类
医药卫生引用本文复制引用
尚俊良,朱艳萍,石春红,徐旭英..甘草油加味治疗糖尿病足游离皮片植皮术后创面的临床观察[J].现代中医临床,2024,31(3):1-6,20,7.基金项目
国家自然科学基金面上项目(No.82174388) （No.82174388）
