动物医学进展2024，Vol.45Issue(7)：82-87,6.
氟苯尼考原料药及制剂在大鼠体内的药代动力学及绝对生物利用度研究
Pharmacokinetics and Absolute Bioavailability Study of Florfenicol Raw Materials and Preparations in Rats
戴银娣 1王聪 2孙少辉 2马小平 1胡娟 1孙莹 1万进 2马妮妮 2杨秋实 2张少南2
作者信息
- 1. 中牧南京动物药业有限公司,江苏南京 210012
- 2. 中牧实业股份有限公司,北京 100070
- 折叠
摘要
Abstract
The present study was conducted to investigate the pharmacokinetic profiles and bioavailability of florfenicol preparations in rats by different means of administration,and to evaluate the effect of β-cyclo-dextrin inclusion technology on the in vivo bioavailability of florfenicol.In this experiment,15 healthy rats were selected and randomly divided into three groups:Florfenicol raw material intravenous injection group,oral administration of a physical mixture of florfenicol group,and oral administration of florfenicol group by inclusion technology alone.The concentration of florfenicol in rat plasma was determined by high-per-formance liquid chromatography(HPLC).Pharmacokinetic data analysis was conducted using non-com-partmental model-dependent statistical moment analysis model in PKSolver software.Pharmacokinetic pa-rameters were calculated to investigate the pharmacokinetic characteristics and bioavailability of florfenicol group by inclusion technology after intravenous injection and oral administration.The results showed that the peak time(Tmax)of the florfenicol group by inclusion technology was 40.00±14.14 min,the peak con-centration(Cmax)was 28.82±4.00 μg/mL,the half-life(t1/2)was 378.40±226.34 min,and the average area under the concentration-time curve(AUC)was 5 627.60±1 442.41.The peak time(Tmax)of the physical mixture group was 68.00±30.33 min,the peak concentration(Cmax)was 15.64±4.40 μg/mL,the half-life(t1/2)was 288.29±52.25 min,and the average AUC was 3 319.22±733.59.The absolute bio-availability of florfenicol powder physical mixture group was 68.8％,while that of the florfenicol group by inclusion tech-nology was 85.0％.In conclusion,the inclusion complex technology of florfenicol product significantly im-proved the absorption extent of florfenicol in vivo,resulting in a higher bioavailability.关键词
氟苯尼考/包合工艺/药代动力学/大鼠Key words
florfenicol/inclusion technology/pharmacokinetics/rat分类
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戴银娣,王聪,孙少辉,马小平,胡娟,孙莹,万进,马妮妮,杨秋实,张少南..氟苯尼考原料药及制剂在大鼠体内的药代动力学及绝对生物利用度研究[J].动物医学进展,2024,45(7):82-87,6.
