口腔疾病防治2024，Vol.32Issue(8)：606-613,8.DOI:10.12016/j.issn.2096-1456.2024.08.005
牙周炎与哮喘的因果关系:一项两样本孟德尔随机化研究
Causal relationship between periodontitis and asthma:a two-sample Mendelian randomization study
摘要
Abstract
Objective To explore the bidirectional causal relationships between periodontitis and asthma using the two-sample Mendelian randomization(MR)method to provide a basis for exploring the etiology and formulating preven-tive and therapeutic measures of periodontitis and asthma.Methods We performed two-sample bidirectional Mende-lian randomization analysis using publicly released European genome-wide association studies(GWAS)statistics for periodontitis(n=34 615)and asthma(n=408 422).The inverse variance weighted(IVW)method was employed as the main approach to estimate the bidirectional causal relationships between periodontitis and asthma.In addition,weighted median(WM),MR-Egger regression,maximum likelihood,and Mendelian randomization robust adjusted profile score(MR-RAPS)were used as supplementary analyses.Sensitivity analyses were conducted using Cochran's Q test,Mende-lian randomization pleiotropy residual sum and outlier(MR-PRESSO),and leave-one-out analysis.Results A total of 12 and 43 single-nucleotide polymorphisms(SNPs)were included as instrumental variables for periodontitis and asthma,respectively.The results of IVW,WM,MR-Egger regression,maximum likelihood,and MR-RAPS showed that periodon-titis was not causally related to the risk of asthma(IVW:OR:1.003,95%CI:0.973-1.035,P=0.828,WM:OR:0.990,95%CI:0.951-1.031,P=0.641;MR-Egger regression:OR:0.988,95%CI:0.960-1.028,P=0.573;maximum likeli-hood:OR:1.003,95%CI:0.972-1.035,P=0.834;MR-RAPS:OR:1.002,95%CI:0.970-1.036,P=0.890)among the European population,and no causal effect of asthma on periodontitis was found(IVW:OR:1.021,95%CI:0.938-1.111,P=0.633,WM:OR:1.011,95%CI:0.894-1.142,P=0.866;MR-Egger regression:OR:1.042,95%CI:0.824-1.319,P=0.731;maximum likelihood:OR:1.021,95%CI:0.938-1.112,P=0.631;MR-RAPS:OR:1.017,95%CI:0.931-1.110,P=0.713)among the European population.Cochran's Q test showed no heterogeneity among the included in-strumental variables,MR-PRESSO test found no horizontal pleiotropy,and the leave-one-out method did not identify out-lier SNPs.Conclusion The results of this study,based on European genetic data,do not support a bidirectional causal association between periodontitis and asthma in the European population.关键词
牙周炎/哮喘/孟德尔随机化/全基因组关联分析/单核苷酸多态性/因果关联/双向因果/工具变量/敏感性分析Key words
periodontitis/asthma/Mendelian randomization/genome-wide-association study/single nucleo-tide polymorphism/causal association/bidirectional casual association/instrumental variable/sensitivity analysis分类
医药卫生引用本文复制引用
陈麒伟,柳汀,蔡扬..牙周炎与哮喘的因果关系:一项两样本孟德尔随机化研究[J].口腔疾病防治,2024,32(8):606-613,8.基金项目
国家自然科学基金(82260185) （82260185）
贵州省卫生厅科技基金(gzwkj2022-166) This study was supported by the grants from the National Natural Science Foundation of China(No.82260185)and Sci-ence-Technology Foundation of Health Commission of Guizhou Province(No.gzwkj2022-166). （gzwkj2022-166）
