口腔疾病防治2024，Vol.32Issue(8)：625-631,7.DOI:10.12016/j.issn.2096-1456.2024.08.008
口腔疾病与抑郁症的关系
Relationship between oral diseases and depression
摘要
Abstract
Oral health is an integral component of overall well-being,with the oral cavity serving as a channel for ex-ternal communication and expression of emotions such as stress and pessimism.Oral diseases can intensify feelings of depression,whereas depression can worsen oral health conditions.As a crucial part of the human microbiome,an imbal-ance in oral microbiota can release oral pathogenic microbes,which,through pathways including the circulation,ner-vous,and immune systems,can reach the brain and significantly affect the central nervous system.This can lead to dys-regulation of the hypothalamic-pituitary-adrenal(HPA)axis,further intensifying the development of depression.Similarly,an imbalance in oral microbiota in individuals with depression can intensify the occurrence of oral diseases.The rela-tionship between depression and oral diseases is not isolated but rather a complex interplay in which they mutually in-fluence and act as causative factors.To elucidate the causal relationship between oral diseases and depression and de-vise strategies for the prevention and treatment of both conditions,we explore the interaction mechanisms between oral diseases and depression from the perspective of oral microbiota.The occurrence of dental caries,periapical periodonti-tis,and periodontal diseases is closely associated with the excessive proliferation of specific bacteria in the oral cavity,such as Streptococcus mutans,Porphyromonas gingivalis,and Fusobacterium nucleatum.These bacteria can directly in-vade the brain through the compromised blood-brain barrier,activating pro-inflammatory cytokines and worsening de-pressive symptoms.Inflammatory conditions and ulcers in the oral mucosa are caused by various factors,including infec-tion and immune abnormalities.Because of compromised immune function in individuals with depression,these inflam-matory responses are often more severe and difficult to control.Malocclusion,trigeminal neuralgia,and temporomandibu-lar joint disorders increase the risk of depression because of psychological stress and changes in the immune system.We also outline the diagnostic and therapeutic considerations for oral diseases in patients with depression,emphasizing the importance of early intervention for disease management.Future research will explore the therapeutic potential of oral microbiota in individuals with depression,with the aim to improve symptoms and treatment outcomes by adjusting oral microbiota,thus providing novel avenues for the prevention and treatment of depression.关键词
口腔疾病/口腔健康/抑郁症/口腔微生态/口腔病原微生物/中枢神经系统/免疫系统/下丘脑-垂体-肾上腺轴/互作机制Key words
oral diseases/oral health/depression/oral microbiota/oral pathogenic microorganisms/central nervous system/immune system/hypothalamus-pituitary-adrenal axis/interactions mechanism分类
医药卫生引用本文复制引用
梁潇月,任彪,周学东..口腔疾病与抑郁症的关系[J].口腔疾病防治,2024,32(8):625-631,7.基金项目
国家自然科学基金项目(81870754) This study was supported by the National Natural Science Foundation of China(No.81870754). （81870754）
