高师理科学刊2024，Vol.44Issue(5)：40-45,6.DOI:10.3969/j.issn.1007-9831.2024.05.008
胃癌中circRNA相关ceRNA预后调控网络的生成方法
Generation method of prognostic regulatory networks of ceRNA related with circRNA in gastric cancer
摘要
Abstract
To describe the regulatory networks of competing endogenous RNA(ceRNA)related with circRNA in gastric cancer,the expression profiles of gastric cancer circRNA,miRNA and mRNA were retrieved from GEO and TCGA databases,and differentially expressed RNAs were identified,key modules were identified using the weighted gene co expression network(WGCNA).Lasso-Cox regression analysis on key module genes was performed,while survival analysis was conduct.Differential expression analysis identified 115 circRNAs and 628 miRNAs,WGCNA constructed 15 circRNA modules and 11 mRNA modules.Lasso Cox analysis identified 4 mRNAs.A series of dysregulated circRNAs,miRNAs,and mRNAs were screened,and a ceRNA network related to circRNA in gastric cancer was constructed.The constructed network can deepen the understanding of circRNA related regulatory mechanisms.关键词
胃癌/WGCNA/Lasso-Cox回归分析/ceRNA调控网络Key words
gastric cancer/WGCNA/Lasso-Cox regression analysis/ceRNA regulatory network分类
信息技术与安全科学引用本文复制引用
杜晓昕,于欢,王波,张剑飞,周薇..胃癌中circRNA相关ceRNA预后调控网络的生成方法[J].高师理科学刊,2024,44(5):40-45,6.基金项目
黑龙江省高校自然科学类青年创新人才项目(145209206) （145209206）
