广西医学2024，Vol.46Issue(3)：376-381,6.DOI:10.11675/j.issn.0253-4304.2024.03.09
18F-FDG PET/CT代谢参数联合临床病理特征对晚期结直肠癌患者KRAS基因突变的评估价值
Evaluation value of 18F-FDG PET/CT metabolic parameters combined with clinicopathological features on KRAS gene mutation in patients with advanced colorectal cancer
摘要
Abstract
Objective To investigate the evaluation value of 18F-fluorodeoxyglucose(18F-FDG)PET/CT metabolic parameters combined with clinicopathological features on Kirsten rat sarcoma viral oncogene homolog(KRAS)gene mutation in patients with advanced colorectal cancer.Methods The clinical data of 64 patients with advanced colorectal cancer were retrospectively analyzed.All patients underwent 18F-FDG PET/CT examination before treatment.The relations of maximal standard uptake value(SUVmax),metabolic tumor volume(MTV)and total lesion glycolysis(TLG)in different thresholds,clinicopathological features with KRAS gene mutation status of patients were analyzed.The multivariate Logistic regression model was used to analyze the factors related to KRAS gene mutation in patients.The receiver operating characteristic curve was employed to analyze 18F-FDG PET/CT metabolic parameters,clinicopathological features,and the two as above for alone and jointly evaluating the efficiency of patients'KRAS gene mutation.A nomogram model was established based on 18F-FDG PET/CT metabolic parameters and clinicopathological features.Results The results of univariate and multivariate Logistic regression analysis revealed that SUVmax≥19.55,MTV50%≥7.95,and tumor tissues with medium/high differentiation were related to patients'KRAS gene mutation.Areas under the curve(AUC)of SUVmax,MTV50%,and differentiated degree of tumor tissues for evaluating patients'KRAS gene mutation were 0.653,0.625,and 0.621,respectively,and AUC of combined evaluation of the three was 0.800,which was higher than AUC of the single index(P<0.05).The consistency index of the nomogram model established based on SUVmax,MTV50%,and differentiated degree of tumor tissues was 0.800,and the calibration curve basically fitted the reference line.Conclusion Metabolic parameters SUVmax and MTV50%of 18F-FDG PET/CT are closely related to KRAS gene mutation in patients with advanced colorectal cancer.The nomogram model established by combining differentiated degree of tumor tissues exerts relatively high evaluation value on patients'KRAS gene mutation.关键词
结直肠癌/鼠类肉瘤病毒癌基因/18F-氟代脱氧葡萄糖/正电子发射计算机体层扫描/代谢参数/临床病理特征/列线图/预测价值Key words
Colorectal cancer/Kirsten rat sarcoma viral oncogene homolog gene/18F-fluorodeoxyglucose/Positron emission computer tomography/Metabolic parameters/Clinicopathological features/Nomogram/Predictive value分类
医药卫生引用本文复制引用
庞丁华,丘文明,黄明捷,黄馨,肖国有,劳永聪..18F-FDG PET/CT代谢参数联合临床病理特征对晚期结直肠癌患者KRAS基因突变的评估价值[J].广西医学,2024,46(3):376-381,6.基金项目
广西科技计划项目(桂科AB19110015) （桂科AB19110015）
广西生物靶向诊治研究重点实验室开放课题(GXSWBX202203,GXSWBX202204,GXSWBX202205) （GXSWBX202203,GXSWBX202204,GXSWBX202205）
