广州医药2024，Vol.55Issue(4)：360-364,5.DOI:10.3969/j.issn.1000-8535.2024.04.004
婴儿孤独症观察量表中文版的临床应用研究
Clinical application of the Chinese version of the Autism Observation Scale for Infants
摘要
Abstract
Objective To test the sensitivity and specificity of the Chinese version of the Autism Observation Scale for Infants(AOSI)in clinical application and evaluate its clinical application effect.Methods Forty-eight children with autism spectrum disorder(ASD)diagnosed at the age of 2 to 3 years who had undergone AOSI evaluation in Qingyuan Maternal and Child Health Hospital at the age of 1 year(2021)were randomly selected as the ASD group,and 46 children with normal development were randomly selected as the control group.The scores of 18 items and total scores of the two groups of subjects were compared.The specificity,sensitivity,positive predictive value and negative predictive value of AOSI were calculated using the receiver operating characteristic curve(ROC),and the best diagnostic(positive)cut-off value of AOSI was confirmed.The consistency of AOSI evaluation results with the ASD diagnostic criteria in DSM-5 were compared.Results There was no statistically significant difference in genders or age between two groups(P＞0.05).The scores of each item and total scores in the ASD group were significantly higher than those in the control group,and the difference was statistically significant(P＜0.01).The area under the curve of AOSI(AUC=1.00,P＜0.01)had a 95%confidence interval of(1.00,1.00).Comparing the sensitivity,specificity,positive predictive value,negative predictive value and consistency of different positive boundary points,when the Youden index was equal to 1.00,the optimal diagnostic(positive cut-off value)boundary for AOSI was 9 points,and all of the above values were 1.00.The AOSI evaluation results were completely consistent with the diagnostic criteria for ASD in DSM-5(Kappa=1,P＜0.01).Conclusions AOSI has high sensitivity and specificity when it is used to evaluate the 1-year-old infant.When"9 points"is taken as the diagnostic threshold,it can better predict whether the infant has ASD at the age of 2～3 years.AOSI is an important tool for screening ASD in infancy.Its evaluation results can be used as evidence for early intervention of high-risk infants with ASD and as a assisting tool to diagnosis ASD,which is suitable for clinical application.关键词
婴儿/婴儿孤独症观察量表/评估Key words
infant/the Autism Observation Scale for Infant/assessment引用本文复制引用
彭琼,凡伟,黄肖霞,李秋婵,胡卓坚,郭碧华,温慧玲,吴文华..婴儿孤独症观察量表中文版的临床应用研究[J].广州医药,2024,55(4):360-364,5.基金项目
2022年广东省医学科研基金(A2022119) （A2022119）
广东省清远市科技计划项目(221025227687333) （221025227687333）
