广州医药2024，Vol.55Issue(4)：401-405,5.DOI:10.3969/j.issn.1000-8535.2024.04.012
环泊酚应用于老年患者无痛胃肠镜的临床研究
Clinical study on the application of ciprofol in elderly patients undergoing painless gastroenteroscopy
摘要
Abstract
Objective To observe the effect of ciprofol and propofol in painless gastroenteroscopy in elderly patients.Methods A total of 80 elderly patients aged 65 or above who underwent painless gastroenteroscopy were randomly divided into a group of 40 patients receiving ciprofol(Group C)and a group of 40 patients receiving propofol(Group P).All patients were given sufentanil 0.08 μg/kg,and group C was given ciprofol 0.3 mg/kg,group P was given propofol 1.5 mg/kg after 30 seconds.The heart rate(HR)and mean arterial pressure(MAP)of two groups of patients before anesthesia(T0),at the disappearance of eyelash reflex(T1),after gastroscopy insertion(T2),and at the end of the procedure(T3)were recorded.The operating time,anesthesia awakening time,number of additional medications and the adverse reactions such as injection pain,respiratory depression,cough,body movements were also recorded.Results There were no significant differences(P＞0.05)in the gastroenteroscopy operating time,recovery time and number of additional medications between the two groups.Compared with T0 time point(102.6±14.1 mmHg),the MAP of group P patients significantly decreased at T1(86.0±12.5 mmHg),T2(86.1±13.2 mmHg)and T3(92.8±12.6 mmHg)time points(P＜0.05).Compared with Group C at T1(95.9±10.8 mmHg),T2(96.3±9.6 mmHg)time points,the MAP of Group P decreased significantly at T1(86.0±12.5 mmHg)and T2(86.1±13.2 mmHg)time points(P＜0.05).The incidences of injection pain and respiratory depression in group C were significantly lower than those in group P(P＜0.05).There was no statistically significant difference in the incidences of body movements and cough between the two groups(P＞0.05).Conclusions Ciprofol 0.3 mg/kg combined with sufentanil can provide anesthesia effect similar to that of propofol 1.5 mg/kg combined with sufentanil in gastroenteroscopy of elderly patients.The proportions of injection pain,blood pressure decreasing and respiratory depression in elderly patients in the ciprofol group were lower.关键词
环泊酚/老年患者/无痛胃肠镜Key words
ciprofol/elderly patients/painless gastroenteroscopy引用本文复制引用
张耀贤,刘英男,崔媛媛,刘喜成,郑子豪..环泊酚应用于老年患者无痛胃肠镜的临床研究[J].广州医药,2024,55(4):401-405,5.基金项目
广东省医学科学技术研究基金(C2021105) （C2021105）
深圳市人民医院临床研究培育项目(SYLCYJ202113) （SYLCYJ202113）
