广州医药2024，Vol.55Issue(4)：416-422,7.DOI:10.3969/j.issn.1000-8535.2024.04.015
靳三针联合解语丹治疗卒中后失语症的临床疗效研究
Clinical efficacy of Jin's Three Needle combined with Jieyu Dan in the treatment of aphasia after stroke
摘要
Abstract
Objective To compare the therapeutic effects of different treatment plans based on Jieyu Dan combined with Jin's Three Needle on aphasia patients after stroke.Methods A total of 120 patients with aphasia after stroke in the neurology and traditional Chinese medicine departments of Guangzhou First People's Hospital were collected and randomly divided into Jieyu Dan group,Jin's Three Needle group,combined group and control group,with 30 cases in each group.The treatment groups were treated with Jieyu Dan,Jin's Three Needle and Jieyu Dan combined with Jin's Three Needle respectively,in addition to conventional stroke treatment.The control group was only treated with conventional stroke treatment,with a total treatment period of 12 weeks.The Western Aphasia Battery(WAB),Aphasia Battery of Chinese(ABC)and Treatment Emergent Symptom Scale(TESS)were used to evaluate patients before,at 2 weeks and 12 weeks of the trial,and drug safety was evaluated to observe the clinical therapeutic effect of Jieyu Dan combined with Jin's Three Needle in treating post stroke aphasia.Results After 2 weeks of treatment,the aphasia quotient(AQ),performance quotient(PQ),cortical quotient(CQ)scores of WAB in each group of the experimental group were 68.14±7.23,67.26±7.23,69.73±6.97;15.47±3.91,15.92±6.35,18.06±7.83;66.84±7.85,65.78±6.75,70.35±6.73,respectively,and all significantly improved compared to before treatment and the control group,with significant differences(P＜0.05).Compared with the experimental group,the combined group had better scores than the Jieyu Dan group and Jin's Three Needle group,with a statistically significant difference(P＜0.05).After 12 weeks of treatment,the AQ,PQ,and CQ scores of the experimental group's WAB were 91.87±7.81,85.75±6.87,94.58±7.83;31.57±7.38,25.67±6.28,35.72±8.31;89.74±6.98,84.16±6.79,93.56±7.88,respectively.Compared with 2 weeks of treatment,the difference was statistically significant(P＜0.05).The scores of each sub item of speech function showed that the combined group was significantly better than the other groups in terms of oral expression,listening comprehension,retelling,naming,etc.,with statistical significance(P＜0.05).At 2 and 12 weeks,there were no significant statistical differences in TESS scores among the experimental groups(P＜0.05).Statistical analysis showed that the combination of Jieyu Dan and Jin's Three Needle in the treatment of post-stroke aphasia had a more significant effect after 2 weeks and 12 weeks.Conclusions The combination of Jieyu Dan and Jin's Three Needle can effectively improve cognitive function and enhance patients'self-care ability in the early treatment of aphasia after stroke.The clinical efficacy is significant and has good safety,making it an effective treatment plan for aphasia after stroke.关键词
卒中后失语症/解语丹/靳三针/西方失语成套测验/汉语失语检查量表/副反应量表Key words
post-stroke aphasia/Jieyu Dan/Jin's Three Needle/Western Aphasia Battery(WAB)/Aphasia Battery of Chinese(ABC)/Treatment Emergent Symptom Scale(TESS)引用本文复制引用
叶海霞,李世林..靳三针联合解语丹治疗卒中后失语症的临床疗效研究[J].广州医药,2024,55(4):416-422,7.基金项目
广东省中医药局科研项目(20201288) （20201288）
