表没食子儿茶素没食子酸酯对脓毒症肠道损伤的影响及机制研究OA北大核心CSTPCD
Effect and mechanism of epigallocatechin gallate on intestinal injury in sepsis
目的:探讨表没食子儿茶素没食子酸酯(epigallocatechin gallate,EGCG)对脓毒症大鼠肠道损伤的影响及机制.方法:随机将 32 只雄性SD大鼠分为假手术组(Sham组)、脓毒症组(CLP组)、脓毒症+EGCG组(EGCG组)、脓毒症+GSK2606414干预组(GSK组),每组各8只.Sham组开腹后仅观察盲肠后立即关腹;CLP组采用盲肠结扎穿孔术;EGCG组在CLP术后腹腔注射 50 mg/kg的EGCG;GSK组在CLP…查看全部>>
Objective:To investigate the effect and mechanism of epigallocatechin gallate(EGCG)on intestinal injury in sep-sis rats.Methods:32 Male SD rats were randomly divided into Sham group(Sham group),sepsis group(CLP group),sepsis+EGCG group(EGCG group)and sepsis+GSK2606414 intervention group(GSK group),with 8 rats in each group.In Sham group,only the cecum was observed and the abdomen was closed immediately after laparotomy.Caecal ligation and perforation were pe…查看全部>>
黄玮玮;马涛;李志华;王毅;高晓明;于湘友
新疆医科大学第一附属医院重症医学中心,新疆 乌鲁木齐 830054||新疆医科大学,新疆 乌鲁木齐 830054新疆医科大学第一附属医院重症医学中心,新疆 乌鲁木齐 830054||新疆医科大学,新疆 乌鲁木齐 830054新疆医科大学第一附属医院重症医学中心,新疆 乌鲁木齐 830054||新疆医科大学,新疆 乌鲁木齐 830054新疆医科大学第一附属医院重症医学中心,新疆 乌鲁木齐 830054||新疆医科大学,新疆 乌鲁木齐 830054新疆医学动物模型研究重点实验室,新疆 乌鲁木齐 830054新疆医科大学第一附属医院重症医学中心,新疆 乌鲁木齐 830054||新疆医科大学,新疆 乌鲁木齐 830054
临床医学
脓毒症肠道损伤表没食子儿茶素没食子酸酯内质网应激凋亡
SepsisIntestinal injuryEpigallocatechin gallateEndoplasmic reticulum stressApoptosis
《海南医学院学报》 2024 (10)
731-738,8
This study was supported by National Natural Science Foundation of China(82160360)Science and Technology Branch Project of Xinjiang Uygur Autonomous Region(2021E02064) 国家自然科学基金资助项目(82160360)新疆维吾尔自治区科技支疆项目(2021E02064)
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