海南医学院学报2024，Vol.30Issue(10)：790-794,5.DOI:10.13210/j.cnki.jhmu.20231012.001
双链蛋白聚糖Biglycan在骨退行性疾病中的作用机制研究进展
Research progress on the mechanism of action of Biglycan in bone degenerative diseases
摘要
Abstract
Biglycan is a recently discovered small leucine-rich proteoglycan,widely found in various connective tissues.It has a key role in many organs and systems,and leads to the occurrence and development of a variety of diseases by participating in the whole process of cell growth and apoptosis.In recent years,with the deepening of research,Biglycan has been confirmed to lead to the occurrence and development of bone degenerative diseases by regulating the expression of extracellular matrix,inhibiting the differentiation of osteoblasts and promoting the activation of osteoclast precursor cells.This article aims to provide new ideas for clinical diagnosis and treatment activities by elaborating the role of Biglycan in bone degenerative diseases(Osteoporosis,Osteoar-thritis,and Intervertebral disc degeneration).关键词
Biglycan/骨质疏松症/骨关节炎/椎间盘退行性病变Key words
Biglycan/Osteoporosis/Osteoarthritis/Intervertebral disc degeneration分类
医药卫生引用本文复制引用
符永华,李吉,王裕倩,邓小中,崔红旺..双链蛋白聚糖Biglycan在骨退行性疾病中的作用机制研究进展[J].海南医学院学报,2024,30(10):790-794,5.基金项目
This study was supported by Hainan Province Key Research and Development Project(ZDYF2021SHFZ084) 海南省重点研发项目(ZDYF2021SHFZ084) （ZDYF2021SHFZ084）
