湖北体育科技2024，Vol.43Issue(3)：94-99,6.
阿里红黄酮减轻低氧力竭运动大鼠脑组织损伤的机制研究
Study on the Mechanism of Brain Tissue Injury in Rats Induced by Hypoxic Exhaustive Exercise by Fomes Officinalis Ames Flavone
摘要
Abstract
Objective To investigate the effects of Fomes Officinalis Ames Flavone(FOF)on cognitive ability,neuroinflammation,and microglia activation in long-term hypoxic exhaustive exercise rats.Methods Sixty male rats were randomly divided into NC group,HE group,HE+LFOF group,HE+MFOF group and HE+HFOF group.The HE group,HE+LFOF group,HE+MFOF group,and HE+HFOF group rats received continuous 6 weeks of exhausted treadmill exercise.The HE+LFOF group,HE+MFOF group,and HE+HFOF group were gavaged with 100,200 and 400 mg·kg-1·d-1 of Alirubin 30 minutes after each exercise.Evaluate the autonomous activity and spatial memory ability of rats after intervention.Detect brain tissue inflammation,oxidative stress response,and activation of mi-croglia.Results Compared with HE group,the total exercise distance,number of grates crossed,average swimming speed,number of platform crossing,residence time in the quadrant where the platform was located,SOD and GSH-px concentrations in brain tissue were significantly increased in HE+LFOF group(p＜0.05),HE+MFOF group and HE+HFOF group.The activity time of central region,the escape latency period(1d～5d),the concentration of IL-1β,IL-6 and TNF-α in brain tissue,the protein expressions of MDA,IL-1β,COX-2,Iba-1 and GFAP in brain tissue were significantly decreased(p＜0.05).Conclusion FOF of 100～400 mg·kg1 can in-hibit brain tissue damage in long-term hypoxic exhaustive exercise rats and improve their autonomous activity and spatial memory abili-ties.关键词
低氧力竭运动/阿里红黄酮/大鼠/脑组织损伤Key words
hypoxic exhaustive exercise/Fomes Officinalis Ames Flavone/rats/brain tissue injury分类
社会科学引用本文复制引用
孔海军,李新龙..阿里红黄酮减轻低氧力竭运动大鼠脑组织损伤的机制研究[J].湖北体育科技,2024,43(3):94-99,6.基金项目
2020年新疆维吾尔自治区喀什地区科技计划(KS20200024). （KS20200024）
