湖北体育科技2024，Vol.43Issue(3)：100-106,7.
运动预干预对脑缺血再灌注大鼠学习记忆的影响及机制
Effects of Exercise Preintervention on Learning and Memory and Synaptic Proteins Ex-pression in Hippocampus CA1 of the Cerebral Ischemia Reperfusion Rats
摘要
Abstract
Objetive The aim of the present study was to explore the possible mechanism of 4 weeks treadmill exercise preintervention in improving cognitive function of cerebral ischemia reperfusion(CI/R)rats by measuring the cerebral infarction volume,hippocampus inflammatory biomarkers levels and the synaptic proteins expression in hippocampus CA1.Methods 40 SD male rats were modeled for CI/R and the CI/R exercise group rats were subjected to 4 weeks of incremental load treadmill exercise before modeling.After 72 h of CI/R,the learning and memory ability of rats were evaluated,the cerebral infarction volume％,the level of TNF-α,IL-6 in hip-pocampus and the expression of SYN and PSD-95 in hippocampal CA1 region were measured.Results 1)Compared with the sham operation group,the escape latency significantly increased and the number of crossing the platform significantly decreased in the morris water mazet test;cerebral infarction volume％and the level of IL-6 and TNF-α in hippocampus significantly increased,while the MOD of SYN and PSD-95 in hippocampus CA1 significantly decreased.2)The 4-week treadmill exercise preintervention can signifi-cantly improve the learning and memory ability of CI/R rats,the cerebral infarction volume％and the TNF-α level in hippocampus significantly decreased;the MOD of SYN and PSD-95 had a significant up-regulation in hippocampus CA1 region in CI/R exercise group rats when compared with the CI/R model group.Conclusion Treadmill exercise preintervention might prevent memory deficits after CI/R through reducing hippocampal neuroinflammatory response,reducing cerebral infarction volume and increasing the synaptic associated protein expression in hippocampal CA1,which is considered to be an effective strategy to prevent ischemic injury.关键词
跑台运动预干预/脑缺血再灌注/学习记忆/海马炎症因子/突触素表达Key words
exercise preintervention/cerebral ischemia reperfusion/learning and memory/hippocampal inflammatory cytokines/synaptophysin expression分类
社会科学引用本文复制引用
杨子欣,王艳红,凌小妹,宋艳丽,苏晓云,贺继平..运动预干预对脑缺血再灌注大鼠学习记忆的影响及机制[J].湖北体育科技,2024,43(3):100-106,7.基金项目
山西省自然科学基金项目(20210302123060). （20210302123060）
