郑州大学学报（医学版）2024，Vol.59Issue(3)：331-335,5.DOI:10.13705/j.issn.1671-6825.2023.04.072
卵母细胞玻璃化冷冻与胚胎玻璃化冷冻移植周期的临床妊娠及围产期结局比较
Comparative analysis of clinical pregnancy and perinatal outcomes be-tween oocyte vitrification cleavage embryo transfer and embryo vitrifica-tion cleavage embryo transfer
摘要
Abstract
Aim:To compare the clinical pregnancy outcome and perinatal outcome between oocyte vitrification cleav-age embryo transfer and embryo vitrification cleavage embryo transfer.Methods:A retrospective cohort study was conducted to analyze the clinical data of patients who underwent cleavage embryos transfer in the Department of Reproductive Medicine of the Third Affiliated Hospital of Zhengzhou University from January 2011 to June 2021.A total of 77 cycles of fresh cleav-age embryo transfer(embryo originated from vitrified-thawed oocytes,oocyte vitrification group)and 293 cycles of vitrified-thawed embryo transfer(after matching at 1:4 with propensity score matching)(embryo vitrification group)in the same pe-riod were included,intracytoplasmic sperm injection(ICSI)was used in both groups for fertilization.Compare the clinical pregnancy and perinatal outcomes between the 2 groups.Results:Between oocyte vitrification group and embryo vitrification group,there were no significant differences in clinical pregnancy outcomes such as clinical pregnancy rate(50.65％ vs 46.76％),early abortion rate(12.82％ vs 11.68％)and live birth rate(37.66％ vs 39.72％)(P>0.05),or in obstetric outcomes such as cesarean section rate(79.31％vs 83.33％),incidence of premature rupture of membranes(10.34％ vs 9.65％)or incidence of pregnancy-induced hypertension(10.34％ vs 9.65％)(P>0.05),or in single and twin neonatal outcomes such as preterm birth rate(18.75％ vs 6.41％,46.15％ vs 41.67％)and birth weight[(3 449.38±485.39)g vs(3 424.74±511.94)g,(2 515.20±539.46)g vs(2 597.08±523.44)g](P>0.05).Conclusion:Oocyte vitrifi-cation is a relatively safe assisted reproductive technology,with similar clinical pregnancy and perinatal outcomes as embryo vitrification.关键词
卵母细胞/胚胎/玻璃化冷冻/临床妊娠结局/围产期结局Key words
oocyte/embryo/vitrification/clinical pregnancy outcome/perinatal outcome分类
医药卫生引用本文复制引用
申春艳,张建瑞,杜姗姗,管一春..卵母细胞玻璃化冷冻与胚胎玻璃化冷冻移植周期的临床妊娠及围产期结局比较[J].郑州大学学报（医学版）,2024,59(3):331-335,5.基金项目
国家重点研发计划重点专项(2021YFC2700602) （2021YFC2700602）
河南省科技攻关计划联合共建项目(LHGJ20210437) （LHGJ20210437）
