郑州大学学报（医学版）2024，Vol.59Issue(3)：376-380,5.DOI:10.13705/j.issn.1671-6825.2023.05.074
高血压早期肾损害诊断指标的筛选
Screening of diagnostic indicators for early renal damage in patients with hypertension
摘要
Abstract
Aim:To screen diagnostic index of early renal damage in patients with hypertension.Methods:From Janu-ary 2020 to February 2023,hypertensive patients admitted to the Department of Internal Medicine of Henan Provincial Peo-ple's Hospital were chosen.Fifty-one hupertension patients with early renal damage[30 mg/24 hour≤urinary albumin ex-cretion rate(uAER)<300 mg/24 hour](renal damage group),and 51 patients with simple hypertension(control group)were selected.ROC curve was drawn to compare the diagnostic efficacy of serum urea nitrogen(BUN),serum creatinine(SCr),serum homocysteine(HCY),serum retinol-binding protein(RBP),serum cystatin C(CysC),urinary microalbumin(umALB),urinary microalbumin/creatinine ratio(uACR),urinary α1 microglobulin(uα1MG),urinary β2 microglobulin(uβ2MG),urinary N-acetyl-β-D glucosaminidase(uNAG),and urinary transferrin(uTF).Results:The levels of indexes(BUN,SCr,HCY,RBP,CysC,umALB,uAER,uACR,uα1MG,uβ2MG,uNAG,uTF)in renal damage group were signifi-cantly higher than those in control group(all P<0.05);the order of diagnostic efficacy(AUC>0.9)from high to low was as follows:uACR>CysC>uα1MG>uβ2MG>umALB>RBP.Combination of CysC and uACR had the highest diagnostic efficiency[AUC(95%CI)was 0.994(0.954-1.000),sensitivity rate of 1.000].Conclusion:Combination of CysC and uACR has higher diagnostic efficacy of early renal damage in patients with hypertension.关键词
高血压/肾损害/肾功能/24h尿白蛋白排泄率/血清胱抑素C/尿微量白蛋白/肌酐比值Key words
hypertension/kidney damage/kidney function/24 hour urinary albumin excretion rate/serum cystatin C/urinary microalbumin/creatinine ratio分类
医药卫生引用本文复制引用
孔德慧,刘敏..高血压早期肾损害诊断指标的筛选[J].郑州大学学报（医学版）,2024,59(3):376-380,5.基金项目
河南省医学科技攻关计划项目(LHGJ20220002) （LHGJ20220002）
国家自然科学基金面上项目(82270463) （82270463）
