中药通过干预miRNA表达治疗椎间盘退行性变OACSTPCD

The pathogenesis of intervertebral disc degeneration is very complex,including inflammatory,genetic,hereditary,immune and biomechanical factors.Inflammatory response plays a key role in the occurrence of diseases,and the abnormal expression of inflammatory factors can accelerate the progression of diseases.As an important regulatory molecule of gene expression,microRNA(miRNA)has an effect on the occurrence and progression of diseases.By regulating the expression of miRNA,the inflammatory response can be inhibi-ted,and then the intervertebral disc tissue can be repaired.Traditional Chinese medicine has become a new research hotspot in regula-ting intervertebral disc inflammation by interfering with miRNA expression.Traditional Chinese medicine compound formulas such as Shaoyao Gancao Decoction,Duhuo Jisheng Decoction and traditional Chinese medicine monomers such as icariin and total saponins of dipsacus asper can interfere with the inflammatory response by regulating the expression of miRNA,which is expected to slow down the progression of the disease and become potential drugs for the treatment of intervertebral disc degeneration.Therefore,TCM intervention of miRNA expression is a potential therapeutic approach to inhibit the intervertebral disc inflammatory response and thus slow down the progression of the disease.