中医学报2024，Vol.39Issue(6)：1151-1156,6.DOI:10.16368/j.issn.1674-8999.2024.06.192
中药通过干预miRNA表达治疗椎间盘退行性变
Traditional Chinese Medicine Intervenes in miRNA-Mediated Intervertebral Disc Degeneration
摘要
Abstract
The pathogenesis of intervertebral disc degeneration is very complex,including inflammatory,genetic,hereditary,immune and biomechanical factors.Inflammatory response plays a key role in the occurrence of diseases,and the abnormal expression of inflammatory factors can accelerate the progression of diseases.As an important regulatory molecule of gene expression,microRNA(miRNA)has an effect on the occurrence and progression of diseases.By regulating the expression of miRNA,the inflammatory response can be inhibi-ted,and then the intervertebral disc tissue can be repaired.Traditional Chinese medicine has become a new research hotspot in regula-ting intervertebral disc inflammation by interfering with miRNA expression.Traditional Chinese medicine compound formulas such as Shaoyao Gancao Decoction,Duhuo Jisheng Decoction and traditional Chinese medicine monomers such as icariin and total saponins of dipsacus asper can interfere with the inflammatory response by regulating the expression of miRNA,which is expected to slow down the progression of the disease and become potential drugs for the treatment of intervertebral disc degeneration.Therefore,TCM intervention of miRNA expression is a potential therapeutic approach to inhibit the intervertebral disc inflammatory response and thus slow down the progression of the disease.关键词
椎间盘退行性变/miRNA/炎症反应/中药复方/中药单体Key words
intervertebral disc degeneration/miRNA/inflammatory response/traditional Chinese medicine compound formula/traditional Chinese medicine monomer分类
医药卫生引用本文复制引用
马俊飞,赵继荣,史凡凡,蒋鹏,薛旭,杨正汉,陈倩文..中药通过干预miRNA表达治疗椎间盘退行性变[J].中医学报,2024,39(6):1151-1156,6.基金项目
国家自然科学基金项目(81760877) （81760877）
国家中医药管理局基金项目(GZY-FJS-2020-213) （GZY-FJS-2020-213）
甘肃省重大科技项目(21ZD4FA009) （21ZD4FA009）
甘肃省科技厅重点研发计划社会发展类项目(20YF3FA016) （20YF3FA016）
兰州市创新人才项目(2018-RC-99) （2018-RC-99）
