中医学报2024，Vol.39Issue(6)：1171-1176,6.DOI:10.16368/j.issn.1674-8999.2024.06.195
基于NLRP3炎症小体探讨针刺治疗阿尔茨海默病
Acupuncture Treatment of Alzheimer's Disease Based on NLRP3 Inflammasome
摘要
Abstract
Persistent excessive immune inflammatory response plays a key role in the pathogenesis of Alzheimer's disease(AD).NOD-like receptor protein 3(NLRP3)inflammasome is crucial in neuroinflammatory pathways,which is abnormally activated by various stimuli such as amyloid β-protein(Aβ)and triggers AD pathological changes,leading to the decline of cognitive function.NLRP3 in-flammasome may provide a new target for the treatment of AD.Acupuncture can inhibit the activation of NLRP3 inflammasome by regu-lating TLR4/NF-κB signaling pathway and regulating intestinal flora disorder,thereby inhibiting the activation of microglia and the ex-pression of pro-inflammatory cytokines,to play a role in the treatment of AD.In the future,omics technology,high-throughput mass spectrometry and bioinformatics can be used to study from multi-dimensional perspectives,to provide stronger evidence for the preven-tion and treatment of AD with acupuncture.关键词
阿尔茨海默病/针刺/NLRP3炎症小体/神经炎症Key words
Alzheimer's disease/acupuncture/NLRP3 inflammasome/neuroinflammation分类
医药卫生引用本文复制引用
王瑞奇,詹逸珺,裴建..基于NLRP3炎症小体探讨针刺治疗阿尔茨海默病[J].中医学报,2024,39(6):1171-1176,6.基金项目
上海市科学技术委员会科研项目(22Y11922900,18401970500) （22Y11922900,18401970500）
上海市卫生健康委员会海派中医流派传承研究项目[ZY(2021-2023)-0209-10,ZY(2018-2020)-CCCX-1006] （2021-2023）
上海申康重大临床研究项目(SHDC2020CR3091B) （SHDC2020CR3091B）
