活血化瘀中药重塑肿瘤微环境OACSTPCD

"Blood stasis"is not only a pathological induction of the overall hypercoagulable state of the body,but also a high generaliza-tion of the local tumor microenvironment of blood vessel lesions,which is the core element of the understanding of the pathogenesis of tumor in traditional Chinese medicine.Chinese herbs for promoting blood circulation and removing blood stasis can inhibit the growth,proliferation,invasion,and metastasis of tumor cells.It can reshape tumor microenvironment by inducing tumor cell apoptosis and auto-phagy,inhibiting tumor related fibroblast activation,inhibiting tumor neovascularization,improving blood hypercoagulability,preventing extracellular matrix degradation,improving hypoxia microenvironment,correcting acidic microenvironment,inhibiting inflammatory mi-croenvironment,regulating immune microenvironment,etc.In view of the current research status on the remodeling of tumor microenvi-ronment by activating blood circulation and removing blood stasis traditional Chinese medicine,future research should follow the princi-ple of differentiation and treatment of traditional Chinese medicine,pay attention to the spatio-temporal heterogeneity of tumor microen-vironment,explain the mechanism of"Zheng Qi and evil factor interaction"effect between various components of tumor microenviron-ment,carry out real-world research on the pharmacodynamic mechanism and clinical efficacy of activating blood circulation and remo-ving blood stasis traditional Chinese medicine compound,and develop nano drug delivery systems targeting tumor microenvironment.To provide guidance for the accurate differentiation and treatment of tumor disease.