中医学报2024，Vol.39Issue(6)：1188-1194,7.DOI:10.16368/j.issn.1674-8999.2024.06.198
活血化瘀中药重塑肿瘤微环境
Traditional Chinese Medicine for Promoting Blood Circulation and Removing Blood Stasis in Reshaping Tumor Microenvironment
摘要
Abstract
"Blood stasis"is not only a pathological induction of the overall hypercoagulable state of the body,but also a high generaliza-tion of the local tumor microenvironment of blood vessel lesions,which is the core element of the understanding of the pathogenesis of tumor in traditional Chinese medicine.Chinese herbs for promoting blood circulation and removing blood stasis can inhibit the growth,proliferation,invasion,and metastasis of tumor cells.It can reshape tumor microenvironment by inducing tumor cell apoptosis and auto-phagy,inhibiting tumor related fibroblast activation,inhibiting tumor neovascularization,improving blood hypercoagulability,preventing extracellular matrix degradation,improving hypoxia microenvironment,correcting acidic microenvironment,inhibiting inflammatory mi-croenvironment,regulating immune microenvironment,etc.In view of the current research status on the remodeling of tumor microenvi-ronment by activating blood circulation and removing blood stasis traditional Chinese medicine,future research should follow the princi-ple of differentiation and treatment of traditional Chinese medicine,pay attention to the spatio-temporal heterogeneity of tumor microen-vironment,explain the mechanism of"Zheng Qi and evil factor interaction"effect between various components of tumor microenviron-ment,carry out real-world research on the pharmacodynamic mechanism and clinical efficacy of activating blood circulation and remo-ving blood stasis traditional Chinese medicine compound,and develop nano drug delivery systems targeting tumor microenvironment.To provide guidance for the accurate differentiation and treatment of tumor disease.关键词
活血化瘀中药/肿瘤微环境/血瘀Key words
traditional Chinese medicine for promoting blood circulation and removing blood stasis/tumor microenvironment/blood sta-sis分类
医药卫生引用本文复制引用
何伟..活血化瘀中药重塑肿瘤微环境[J].中医学报,2024,39(6):1188-1194,7.基金项目
陕西省教育厅科学研究计划-重点项目(20JS030,23JS007) （20JS030,23JS007）
陕西省重点研发计划项目(2021SF-402,2022SF-316) （2021SF-402,2022SF-316）
