中医学报2024，Vol.39Issue(6)：1224-1230,7.DOI:10.16368/j.issn.1674-8999.2024.06.205
中药调控肠道干细胞延缓衰老研究进展
Research Progress on Delaying Aging with Chinese Medicine by Regulating Intestinal Stem Cell
摘要
Abstract
In traditional Chinese medicine,there is a long history of delaying aging,mainly with deficiency tonifying drugs and blood-activating drugs to remove blood stasis,such as Renshen(Ginseng Radix et Rhizoma),Huangqi(Astragal Radix),Guifu Dihuang Pill,Sijunzi Decoction,Shenqi Baizhu Powder,etc.mainly through the regulation of intestinal stem cell aging related signaling pathways such as Wnt,Notch,MAPK,EGFR,mTOR.It can remove free radicals,improve the activity of antioxidant enzyme,and regulate immune func-tion,so as to delay intestinal aging.However,the specific mechanism of the changes in tissue structure and function caused by intestinal aging is not yet clear,and further studies are needed.Meanwhile,the future research direction is to explore how to apply natural drug safely and effectively in clinical treatment to delay aging.关键词
衰老/肠道干细胞/信号通路/中药/人参/黄芪/桂附地黄丸/四君子汤Key words
aging/intestinal stem cell/signaling pathway/Chinese medicine/Renshen(Ginseng Radix et Rhizoma)/Huangqi(Astragal Radix)/Guifu Dihuang Pill/Sijunzi Decoction分类
医药卫生引用本文复制引用
郭璐璐,李寒冰,李根林,吴宿慧..中药调控肠道干细胞延缓衰老研究进展[J].中医学报,2024,39(6):1224-1230,7.基金项目
河南省中医药科学研究专项项目(20-21ZY1038) （20-21ZY1038）
