中医学报2024，Vol.39Issue(6)：1323-1327,5.DOI:10.16368/j.issn.1674-8999.2024.06.220
冠脉宁通方加味治疗冠心病心力衰竭气虚痰瘀互结水停证
Modified Guanmai Ningtong Formula in Treating Heart Failure of Coronary Heart Disease with Qi Deficiency,Phlegm,Blood Stasis and Water Stagnating Syndrome
摘要
Abstract
Objective:To observe the effectiveness and safety of Guanmai Ningtong Formula in treatment of patients with coronary athero-sclerotic heart disease(CHD)and heart failure.Methods:120 patients with coronary heart failure were divided into two groups(control group and observation group)according to random number table.The control group was treated with conventional drugs(loop diuretics,spironolactone,sacubactril valsartan,β-blocker,sacubactril valsartan sodium tablets),and the observation group was treated with Guanmai Ningtong Formula on the basis of that of the control group.The treatment course of both groups was 4 weeks.The clinical effi-cacy,symptom score and N-terminal B-type natriuretic peptide precursor(NT-proBNP),left ventricular ejection fraction(LVEF),quality of life score,and safety were compared between the two groups after treatment.Results:(1)The effective rate was 91.66%(55/60)in the observation group and70%(42/60)in the control group,the difference between the two groups was statistically signif-icant(P<0.05).(2)After treatment,the scores of TCM symptoms in the two groups were lower than that before treatment;The TCM symptom score of the observation group was(10.71±2.98),which was significantly lower than that of the control group(P<0.05).(3)After treatment,the Minnesota quality of life score of both groups was significantly decreased,and the Minnesota quality of life score of the observation group was(20.16±5.87),which was significantly lower than that of the control group(P<0.05).(4)After treatment,LVEF in both groups was significantly increased,and LVEF in observation group was(51.80±3.58)%,which was signifi-cantly higher than that of the control group(P<0.05).(5)After treatment,the level of NT-proBNP in both groups was significantly decreased,and the level of NT-proBNP in the observation group was(796.49±281.76)ng·L-1,which was significantly lower than that of the control group(P<0.05).(6)There were no obvious adverse reactions after treatment in both groups.Conclusion:Modified Guanmai Ningtong Formula is effective in treating CHD and heart failure(Qi-deficiency,phlegm-stasis and water-stopping syn-drome),which can reduce TCM symptom score,Minnesota quality of life score,NT-proBNP level and increase LVEF.关键词
冠状动脉粥样硬化性心脏病/心力衰竭/气虚痰瘀互结水停证/冠脉宁通方Key words
coronary atherosclerotic heart disease/heart failure/Qi deficiency,Phlegm,stasis and Water stagnation syndrome/Guanmai Ningtong Formula分类
医药卫生引用本文复制引用
张志国,焦丽华,黄兴,高帅飞,连帅杰..冠脉宁通方加味治疗冠心病心力衰竭气虚痰瘀互结水停证[J].中医学报,2024,39(6):1323-1327,5.基金项目
河南省中医药科学研究专项课题项目(20-21ZY2222) （20-21ZY2222）
李庆海全国名老中医药专家传承工作室建设项目{国中医药人教函[2022]75号} （）
