中医学报2024，Vol.39Issue(6)：1328-1332,5.DOI:10.16368/j.issn.1674-8999.2024.06.221
栀黄止痛散联合双氯芬酸二乙胺乳膏剂治疗急性痛风性关节炎
Zhihuang Zhitong Powder Combined with Diclofenac Diethylamine Cream in Treatment of Acute Gouty Arthritis
摘要
Abstract
Objective:To observe the clinical efficacy of Zhihuang Zhitong Powder combined with diclofenac diethylamine emulgel in treatment of acute gouty arthritis(AGA)and its influence on related inflammatory factors.Methods:60 patients with AGA were random-ly divided into control group and observation group,30 cases in each group.The control group was given diclofenac diethylamine emulgel for external use,and the observation group was given Zhihuang Zhitong Powder for local external use in addition to that of the treatment of the control group.Both groups were treated continuously for 7 days.Visual analog scale(VAS)scores,patient global assessment(PGA)scores and numerical rating scale scores before and after treatment were compared between the two groups.NRS score and TCM syndrome score,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interlenkin 1β(IL-1β),interferon-gamma(IFN-γ),interlenkin 4(IL-4)levels,clinical efficacy and adverse reactions.Results:The effec-tive rate was 96.7%in the observation group and 80%in the control group,and the difference between the two groups was statistically significant(χ2=6.30,P=0.003).Compared with the control group after treatment,VSA(Z=-5.35,P=0.00),NRS(Z=-5.32,P=0.00),TCM syndrome score(Z=-6.74,P=0.00),ESR(Z=-2.50,P=0.01),CRP(t=49.066,P=0.00),TNF-α(Z=-5.24,P=0.00),IL-1β(Z=-6.2,P=0.00)were significantly decreased(P<0.05),PGA(Z=-3.42,P=0.00),IFN-γ(Z=-3.66,P=0.00),IL-4(t=4.89,P=0.00)was significantly increased(P<0.05).There wasnosignificant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Zhihuang Zhitong Powder combined with diclofenac diethylamine emulgel can significantly improve the clinical symptoms of AGA patients,which may be related to the regu-lation of related inflammatory factors.关键词
急性痛风性关节炎/栀黄止痛散/双氯芬酸二乙胺乳膏剂/炎症因子Key words
acute gouty arthritis/Zhihuang Zhitong Powder/diclofenac diethylamine emulgel/inflammatory factor分类
医药卫生引用本文复制引用
杨鹏远,孟庆良..栀黄止痛散联合双氯芬酸二乙胺乳膏剂治疗急性痛风性关节炎[J].中医学报,2024,39(6):1328-1332,5.基金项目
国家自然科学基金面上项目(81874456) （81874456）
