纳米药物载体用于治疗胞内菌感染的研究进展OA北大核心CSTPCD

Intracellular bacteria can escape the body's immunity and grow and reproduce normally in the host cell,which are more difficult to remove than extracellular bacteria and can easily cause more serious infections.With traditional antibiotic treatment,the drugs cannot break through the host cell membrane barrier and can easily cause strong toxic side effects and multidrug resistance.Excellent nanocarriers have good biocompatibility and are easy to modify,which is expected to enhance membrane penetration and bacterial targeting of antibacterial drugs through the construction of nanodelivery systems,offering great potential and broad prospects in the treatment of intracellular bacterial infections.This paper introduces various nanoparticles that can be used to treat intracellular bacterial infections,summarizes the mechanisms and methods for enhancing the therapeutic effects of drug nanodelivery systems,and elaborates on the problems that still exist when using nano-drug delivery systems to treat intracellular bacterial infections,in order to provide inspiration for the construction of better drug delivery systems to treat intracellular bacterial infections.