化工学报2024，Vol.75Issue(4)：1153-1166,14.DOI:10.11949/0438-1157.20231326
纳米药物载体用于治疗胞内菌感染的研究进展
Advances in drug nanodelivery systems for the treatment of intracellular bacterial infections
摘要
Abstract
Intracellular bacteria can escape the body's immunity and grow and reproduce normally in the host cell,which are more difficult to remove than extracellular bacteria and can easily cause more serious infections.With traditional antibiotic treatment,the drugs cannot break through the host cell membrane barrier and can easily cause strong toxic side effects and multidrug resistance.Excellent nanocarriers have good biocompatibility and are easy to modify,which is expected to enhance membrane penetration and bacterial targeting of antibacterial drugs through the construction of nanodelivery systems,offering great potential and broad prospects in the treatment of intracellular bacterial infections.This paper introduces various nanoparticles that can be used to treat intracellular bacterial infections,summarizes the mechanisms and methods for enhancing the therapeutic effects of drug nanodelivery systems,and elaborates on the problems that still exist when using nano-drug delivery systems to treat intracellular bacterial infections,in order to provide inspiration for the construction of better drug delivery systems to treat intracellular bacterial infections.关键词
纳米载体/胞内菌/细菌靶向/抗菌策略Key words
nanocarriers/intracellular bacteria/bacterial targeting/antibacterial strategy分类
化学化工引用本文复制引用
巨晓洁,宋婉璐,周宸宇,沈秋彤,廖雨田,龚珏颖,褚良银..纳米药物载体用于治疗胞内菌感染的研究进展[J].化工学报,2024,75(4):1153-1166,14.基金项目
国家自然科学基金项目(22078202) （22078202）
四川大学-中国核动力研究设计院联合创新基金项目(JG2022300) （JG2022300）
