河南农业科学2024，Vol.53Issue(5)：1-9,9.DOI:10.15933/j.cnki.1004-3268.2024.05.001
酶的理性设计在作物育种中的应用进展与前景展望
Progress on Application of Rational Design of Enzyme in Crop Breeding and Prospect
摘要
Abstract
Excellent germplasm resources are important guarantee for food security,and traditional breeding techniques have problems such as long breeding cycles and intensive workloads.With the deep integration of biology and computer technology,the rational design of enzyme used for directional optimization of key crop genes has laid the foundation for greater exploitation of high-quality genetic resources.It further integrates with gene editing and transgenic technologies,and becomes one of the important directions in the exploration of molecular breeding technology.This article elaborated the common methods of rational design of enzyme,such as molecular docking,molecular dynamic simulations,binding free energy evaluation and so on,reviewed the progress on application of rational design of enzyme in improvement of crop quality,stress resistance and biomass,and the future was prospected,to provide reference for the development and utilization of new technologies in crop breeding.关键词
酶/理性设计/作物育种/基因编辑/遗传转化Key words
Enzyme/Rational design/Crop breeding/Gene editing/Genetic transformation分类
农业科技引用本文复制引用
王东辉,王奥轩,何长海,刘志豪,石永春,王燃,王潇然..酶的理性设计在作物育种中的应用进展与前景展望[J].河南农业科学,2024,53(5):1-9,9.基金项目
河南省人民胜利渠保障中心科研项目(2022001) （2022001）
河南省科技攻关项目(212102311092) （212102311092）
国家烟草专卖局生物育种重大科技专项[110202101042(JY-19)] （JY-19）
国家烟草专卖局重点科技项目(110202102033,110202202038) （110202102033,110202202038）
