中国实用神经疾病杂志2024，Vol.27Issue(5)：573-577,5.DOI:10.12083/SYSJ.231261
丁苯酞联合重复经颅磁刺激治疗对帕金森病患者认知功能和脑血流动力学的影响
Effect of butylphthalein combined with repetitive transcranial magnetic stimulation on cognitive function and cerebral hemodynamics in patients with Parkinson's disease
摘要
Abstract
Objective To observe the effect of butylphthalein combined with repetitive transcranial magnetic stimulation(rTMS)on cognitive function and cerebral hemodynamics in patients with Parkinson's disease(PD).Methods A total of 92 patients with Parkinson's disease admitted to the Department of Neurology,the First Affiliated Hospital of Hebei North University from January 2020 to December 2022 were prospectively selected as the research objects.They were divided into two groups by the random number table method.The control group(46 cases)was given conventional treatment,such as levodopa tablets and improving muscle tension,and the observation group(46 cases)was given butylphthalide combined with rTMS on this basis.Before and after treatment,fasting venous blood was extracted to detect the levels of dopamine(DA),5-hydroxytryptamine(5-HT),C-reactive protein(CRP),and the peak velocity(Vp)and average velocity(Vm)of bilateral middle cerebral arteries were examined by transcranial Doppler ultrasound.Montreal cognitive assessment(MoCA)and mini-mental state examination(MMSE)were used to evaluate the cognitive function and symptom improvement of the two groups before and 8 weeks after treatment.Results After treatment,MMSE and MoCA scores in both groups were higher than before treatment,Vp and Vm in observation group were higher than before treatment,5-HT level was higher than before treatment,CRP level was lower than before treatment,the differences were statistically significant(P<0.05).After treatment,MMSE and MoCA scores in observation group were higher than those in control group(26.28±5.28 vs 23.21±4.88,21.93±6.25 vs 18.84±4.13),Vp and Vm were higher than those in control group(73.15±5.63 vs 69.35±4.36,41.69±5.27 vs 35.09±2.43).DA and 5-HT levels were higher than those in control group(5.07±0.55 vs 4.21±3.17,20.24±5.70 vs 15.69±3.49),and CRP levels were lower than those in control group(1.02±0.13 vs 6.16±0.95),with statistically significant differences(P<0.05).The total effective rate was 91.30%in the observation group and 69.57%in the control group,and the difference was statistically significant(P<0.05).Conclusion Butylphthalein combined with rTMS can improve cerebral hemodynamics,reduce inflammatory response,promote dopamine and neuronal transmitter secretion in PD patients,thereby improving clinical symptoms and cognitive function and enhancing therapeutic effect.关键词
丁苯酞/重复经颅磁刺激/帕金森病/认知功能/脑血流动力学Key words
Butylphthalein/Repeated transcranial magnetic stimulation/Parkinson's disease/Cognitive function/Cerebral hemodynamics分类
医药卫生引用本文复制引用
谷伟,孙梓旭,孙光宁,杨继雷,贾海莉,王燕,王宏..丁苯酞联合重复经颅磁刺激治疗对帕金森病患者认知功能和脑血流动力学的影响[J].中国实用神经疾病杂志,2024,27(5):573-577,5.基金项目
河北省卫生健康委科研课题(编号:20231460 （）
20220622) （）
