江汉大学学报（自然科学版）2024，Vol.52Issue(3)：44-50,7.DOI:10.16389/j.cnki.cn42-1737/n.2024.03.005
橘皮素缓解APP/PS1小鼠小胶质细胞过度激活及认知功能障碍
Tangeretin Alleviates Microglia Over-activation and Cognitive Impairment in APP/PS1 Mice
摘要
Abstract
Objective To study the effects of tangeretin(TAN)on cognitive performance,microglia over-activation,and inflammatory factors released in APP/PS1 mice.Methods 2.5-month-old male APP/PS1 mice were treated with TAN orally for 16 weeks.The effects of TAN on alleviating cognitive dysfunction of APP/PS1,microglia over-activation,and inflammatory factors released in the brain were observed.Results It was found that TAN significantly alleviated cognitive impairment in APP/PS1 mice by behavioral testing;the results of immunofluorescence staining demonstrated that TAN significantly alleviated microglia over-activation in the brain of APP/PS1 mice;the results of multifactor analysis showed that TAN significantly increased the levels of anti-inflammatory molecules IL-2 and IL-5 in the mouse brain.Conclusion TAN significantly reduces microglia over-activation,regulates the release of inflammatory factors in the brain of APP/PS1 mice,and alleviates cognitive impairment.关键词
阿尔兹海默症/橘皮素/小胶质细胞/炎症因子Key words
Alzheimer's disease/tangeretin/microglia/inflammatory factors分类
医药卫生引用本文复制引用
于晶,梁征,贺子珊,陈鸿霖,石成英,龚晓康,包建,舒细记..橘皮素缓解APP/PS1小鼠小胶质细胞过度激活及认知功能障碍[J].江汉大学学报（自然科学版）,2024,52(3):44-50,7.基金项目
湖北省自然科学基金面上项目(2022CFB456) （2022CFB456）
