常州大学学报（自然科学版）2024，Vol.36Issue(3)：59-70,12.DOI:10.3969/j.issn.2095-0411.2024.03.007
基于天然多糖的刺激响应型药物控释系统研究进展
Progress on stimuli-responsive drug controlled delivery systems based on natural polysaccharides
摘要
Abstract
Stimuli-responsive drug controlled delivery systems are generally constructed by using natu-ral polysaccharides biomacromolecules or their derivatives as the carriers,and the drug molecules are loaded into these biomacromolecules through chemical binding or physical adsorption.Stimuli-respon-sive natural polysaccharides biomacromolecules can sense the changes of their surroundings and respond to the changes in their physical or chemical properties,and thus the loaded drugs can be released from the carriers through the breakage of chemical bonding between drug and carrier or the degradation of the carrier itself and controlled delivery of the loaded drugs can be achieved.In this paper,we reviewed the commonly used stimuli modes,including exogenous stimuli and endogenous stimuli,single stimu-lus and multiple stimuli,and some of these stimuli modes have been reported by our own group.We believe that this review is of great importance for development of stimuli-responsive drug controlled delivery systems.关键词
刺激响应型/天然多糖/药物控释系统/刺激方式Key words
stimuli-responsiveness/natural polysaccharides/drug controlled delivery systems/stimuli modes分类
化学化工引用本文复制引用
孔泳,梁政崟,芮倩,李尚基,盛焱山,高俊..基于天然多糖的刺激响应型药物控释系统研究进展[J].常州大学学报（自然科学版）,2024,36(3):59-70,12.基金项目
江苏省自然科学基金资助项目(BK20211066) （BK20211066）
南京中医药大学自然科学基金资助项目(XZR2020042). （XZR2020042）
