军事医学2024，Vol.48Issue(5)：382-388,7.DOI:10.7644/j.issn.1674-9960.2024.05.010
基于谱-效关系的强力定眩片舒血管作用药效物质基础研究
Roles of pharmacodynamic substances of QiangliDingxuan tablets in vasodilation based on spectrum-effect relationships
摘要
Abstract
Objective To establish the fingerprints of QiangliDingxuan tablets(QLDX),determine their pharmacody-namic indexes of vasodilation and study the spectrum-effect relationships between the chemical components of QLDX and the property of vasodilation.Methods The rate of vascular relaxation was used as an index to evaluate the extent to which QLDX relaxed isolated superior mesenteric artery ring.The Grey correlation degree and partial least square regression(PLSR)were used to analyze"spectrum-effect"correlations before components with greater contribution to drug efficacy were screened out.Results There were 21 common peaks in the HPLC fingerprint of QLDX,and the similarity exceeded 0.88.A comparison with the chromatogram of the reference substance revealed 14 characteristic peaks.Vasodilative experiments showed that all the 10 batches of samples had vasodilatory effects.The correlation between the 21 chromato-graphic peaks was greater than 0.73.PLSR showed that 11 components were positively correlated with the vasodilatory effect.Six known compounds included parishin A,parishin C,5-hydroxymethylfurfural,luteolin,Linarin and ligustrazine.Conclusion The vasodilatory effect of QLDX results from the combined action of multiple components.Parishin A,parishin C,5-hydroxymethylfurfural,luteolin,Linarin and ligustrazine are positively correlated with this effect,which may be the main pharmacodynamic substance basis of vascular relaxation.关键词
强力定眩片/指纹图谱/谱-效关系/药效物质基础Key words
QiangliDingxuan tablets/fingerprint/spectrum-effect relationship/pharmacodynamic material basis分类
医药卫生引用本文复制引用
闫平,王茂宁,朱君翊,房盼,张航,张彦,张寒..基于谱-效关系的强力定眩片舒血管作用药效物质基础研究[J].军事医学,2024,48(5):382-388,7.基金项目
陕西省榆林市科技局产学研项目(CXY-2020-092) （CXY-2020-092）
西安医学院科研提升计划(2022NLTS076) （2022NLTS076）
西安市科技局农业技术研发项目(21NYYF0062) （21NYYF0062）
西安医学院2021年青年科研基金(2021QN23) （2021QN23）
国家级大学生创新创业训练计划项目(202211840006) （202211840006）
