昆明医科大学学报2024，Vol.45Issue(5)：8-15,8.DOI:10.12259/j.issn.2095-610X.S20240502
MAPK1与NRAS基因多态性与云南汉族人群宫颈上皮内瘤变的相关性
Correlation of MAPK1 and NRAS Gene Polymorphisms with Cervical Intraepithelial Neoplasia in Yunnan Han Population
摘要
Abstract
Objective NRAS and MAPK1 genes are important regulators of the Ras/Raf/MEK/ERK signaling pathway,and their functions and expression levels have been associated with a variety of human tumors.This study aims to investigate the correlation between the rs14804 and rs9340 polymorphic loci of NRAS and MAPK1 genes and the susceptibility to cervical intraepithelial neoplasia(CIN)in Yunnan Han population.Methods 1399 persons of the population were enrolled in the current study,with 416 as the CIN patient group and 983 as the healthy control group.The SNPs loci(rs14804 and rs9340)in the NRAS gene and the MAPK1 gene were genotyped using the TaqMan assays,and the correlation between the two SNPs loci and the risk of CIN was analyzed.Results The difference in the frequency of distribution of SNP locus rs9340 allele(P=0.008)and genotype(P=0.002)of MAPK1 gene in the CIN group versus the control group was statistically significant,and allele A may be associated with a higher risk of developing CIN(OR=1.28,95%CI 1.07～1.54),especially for people in the lower age group(≤50 years)of CIN risk(OR=1.35,95%CI 1.09～1.67).Conclusion rs9340 in the MAPK1 gene might be correlated with the risk of CIN in the Chinese Han population in Yunnan.关键词
宫颈上皮内瘤变/MAPK1/NRAS/单核苷酸多态性/相关性/云南汉族人群Key words
Cervical intraepithelial neoplasia/MAPK1/NRAS/Single nucleotide polymorphism/Correlation/Yunnan Han population分类
医药卫生引用本文复制引用
牛志鑫,汤丽华,史磊,洪超,姚宇峰,严志凌..MAPK1与NRAS基因多态性与云南汉族人群宫颈上皮内瘤变的相关性[J].昆明医科大学学报,2024,45(5):8-15,8.基金项目
国家自然科学基金资助项目(82103190) （82103190）
云南省基础研究计划基金资助项目(202201AY070001-139,202201AU070163) （202201AY070001-139,202201AU070163）
