昆明医科大学学报2024，Vol.45Issue(5)：60-65,6.DOI:10.12259/j.issn.2095-610X.S20240509
ROR1在不同组织学分级浸润性肺腺癌中的表达与临床意义
Expression and Clinical Significance of ROR1 in Different Histologic Types of Invasive Lung Adenocarcinoma
摘要
Abstract
Objective To investigate the expression of receptor tyrosine kinase-like orphan rectetpor 1(ROR1)in invasive lung adenocarcinoma with different histological grades,and to analyze its relationship with histopathological grade of lung adenocarcinoma so as to explore whether it can be used as a potential indicator for the diagnostic evaluation of invasive lung adenocarcinoma.Methods A total of 290 paraffin-embedded tissue specimens of invasive lung adenocarcinoma were collected,and the relationship between ROR1 expression and invasive lung adenocarcinoma grade was statistically analyzed by HE staining sections.Results ROR1 was significantly highly expressed in the poorly differentiated invasive lung adenocarcinoma(P<0.001),the Ki-67 index in the low-differentiated group was significantly higher than that in the high-differentiation and medium-differentiated groups(P<0.001),and the Ki-67 index was higher in the high-expression group than in the low-expression group(P<0.01).Conclusion There are significant differences in the expression levels of ROR1 in different grades of lung adenocarcinoma,and its expression level is closely related to the degree of differentiation and malignancy of invasive lung adenocarcinoma,which makes it possible to become a new biomarker for the diagnosis of lung adenocarcinoma and assist in the evaluation of clinical features and prognosis of lung adenocarcinoma,and provide a scientific basis to formulate personalized treatment strategies for patients.关键词
肺腺癌/ROR1/Ki-67/病理学分级/免疫组化Key words
Lung adenocarcinoma/ROR1/Ki-67/Pathological grading/Immunohistochemistry分类
医药卫生引用本文复制引用
沈旺寻,杨银煜,李灿伟,杨金荣,伍思婧,赵华君,陀晓宇..ROR1在不同组织学分级浸润性肺腺癌中的表达与临床意义[J].昆明医科大学学报,2024,45(5):60-65,6.基金项目
国家级大学生创新创业训练计划基金资助项目(202210678020) （202210678020）
云南省教育厅科学研究基金资助项目(2024J0206) （2024J0206）
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(202001AY070001-103) （202001AY070001-103）
