兰州大学学报（医学版）2024，Vol.50Issue(4)：88-94,7.DOI:10.13885/j.issn.1000-2812.2024.04.014
药物减轻心肌缺血再灌注损伤机制研究的进展
Research progress on the mechanism of drugs in attenuating myocardial ischemia-reperfusion injury
摘要
Abstract
Myocardial ischemia-reperfusion injury is common in myocardial infarction and myocardial ischemia,having a high incidence,high mortality and insufficient prevention and treatment measures.Actively exploring the prevention and treatment of myocardial ischemia-reperfusion injury has been a focus of clinical research.In the past five years,new progress has been made in the study of drugs that can reduce myocardial ischemia-reperfusion injury and the mechanisms.This article focused on the experimental research and clini-cal observation of drugs in the prevention and treatment of myocardial ischemia-reperfusion injury by in-hibiting ferroptosis,apoptosis,necroptosis,pyrosis,oxidative stress and calcium overload and regulating autophagy,endoplasmic reticulum stress and energy metabolism,and also the latest achievements in the pre-vention and treatment of myocardial ischemia-reperfusion injury by nanotechnology and intracoronary drug administration in the past five years,so as to provide a theoretical basis for the prevention and treatment of myocardial ischemia-reperfusion injury.关键词
药物/心肌缺血再灌注/器官保护/细胞凋亡/自噬/氧化应激Key words
medicine/myocardial ischemia-reperfusion/organ protection/apoptosis/autophagy/oxidative stress分类
医药卫生引用本文复制引用
邢阳,赵紫岑,冷玉芳,赵潇,李东阳,兰金辉,刘振,李东斌,王玉,常利娅..药物减轻心肌缺血再灌注损伤机制研究的进展[J].兰州大学学报（医学版）,2024,50(4):88-94,7.基金项目
国家自然科学基金资助项目(82260381) （82260381）
兰州大学医学教育创新发展项目(lzuyxcx-2022-108) （lzuyxcx-2022-108）
