枯草杆菌二联活菌颗粒联合斑蝥酸钠维生素B6辅助治疗在慢性阻塞性肺疾病合并非小细胞肺癌中的效果研究OACSTPCD
目的 探讨枯草杆菌二联活菌颗粒联合斑蝥酸钠维生素B6 辅助治疗在慢性阻塞性肺疾病(COPD)合并非小细胞肺癌(NSCLC)中的效果.方法 选取2020 年1 月—2022 年10 月收治的COPD合并NSCLC 60 例,采用随机数字表法分为观察组和对照组各30 例.2 组均给予化疗联合免疫治疗,在此基础上对照组给予斑蝥酸钠维生素B6治疗,观察组给予枯草杆菌二联活菌颗粒联合斑蝥酸钠维生素B6 治疗,2 组均持续治疗4 个周期.统计2 组治疗4 个周期后总缓解率及治疗前、治疗2 个周期、治疗4 个周期肿瘤因子[癌胚抗原(CEA)、癌抗原 125(CA125)、血管内皮生长因子(VEGF)、缺氧诱导因子(HIF-1α)]、免疫功能指标(CD3+、CD4+、CD4+/CD8+)、肠道微生态指标(肠道菌群丰富度、多样性指数)、治疗期间毒副反应、治疗后1 年生存率.结果 2 组总缓解率比较差异无统计学意义(P＞0.05).治疗后2 组CEA、CA125、VEGF、HIF-1α呈下降趋势,CD3+、CD4+、CD4+/CD8+呈升高趋势,差异有统计学意义(P＜0.05).治疗后2 组肠道菌群丰富度、多样性指数呈升高趋势,且观察组高于对照组(P＜0.05).观察组胃肠道反应发生率为16.67%(5/30)低于对照组的46.67%(14/30)(P＜0.05).2 组治疗后 1 年生存率比较差异无统计学意义(P＞0.05).结论 枯草杆菌二联活菌颗粒联合斑蝥酸钠维生素 B6 辅助治疗能有效纠正 COPD 合并NSCLC患者化疗及免疫治疗后肠道菌群紊乱,改善机体免疫应答,抑制肿瘤因子表达,减少毒副反应的发生.
Objective To investigate the efficacy of Live Combined Bacillus Subtilis and Enterococcus Faecium Gran-ules with Multivitamines combined with Disodium Cantharidinate and Vitamin B6 in the treatment of chronic obstructive pulmo-nary disease(COPD)complicated with non-small cell lung cancer(NSCLC).Methods A total of 60 patients with COPD combined with NSCLC from January 2020 to October 2022 were selected and divided into the observation group(n=30)and the control group(n=30)by random number table method.Both groups were given chemotherapy combined with immuno-therapy,on the basis of which the control group was given Disodium Cantharidinate and Vitamin B6,and the observation group was given Live Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines Combined with Disodium Cantharidinate and Vitamin B6.Both groups were treated consecutively for 4 cycles.The total response rate after 4 cycles of treatment and the tumor factors[carcinoembryonic antigen(CEA),cancer antigen 125(CA125),vascular endothelial growth factor(VEGF),hypoxia inducible factor-1α(HIF-1α)],immune function indicators(CD3+,CD4+,CD4+/CD8+),and intestinal microecological index(intestinal flora richness and diversity index),toxic and side effects during treatment,and 1-year survival rate after treatment of the two groups before treatment and after 2 and 4 cycles of treatment were analyzed.Results There was no significant difference in the total remission rate between the two groups(P＞0.05).After treatment,CEA,CA125,VEGF and HIF-1α in the two groups decreased,while CD3+,CD4+and CD4+/CD8+increased,with statistical significance(P＜0.05).After treatment,the intestinal flora richness and diversity index of the two groups showed an increasing trend,which were higher in the observation group than in the control group(P＜0.05).The incidence of gas-trointestinal reactions in the observation group was 16.67%(5/30),which was lower than that in the control group(46.67%,14/30)(P＜0.05).There was no significant difference in 1-year survival rate between the two groups(P＞0.05).Conclusion Live Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines Combined with Disodium Cantharidinate and Vitamin B6 can effectively correct the intestinal flora disturbance in COPD patients with NSCLC after chemotherapy and immunotherapy,improve the immune response,inhibit the expression of tumor factors,and reduce the occurrence of toxic and side effects.
陈俊杰;谢利娜;冀丽佳;田秀丽
075000 河北 张家口,张家口市第一医院呼吸与危重症医学三科
临床医学
肺疾病,慢性,阻塞性肺肿瘤枯草杆菌二联活菌颗粒斑蝥酸钠维生素B6癌胚抗原CD3+毒副反应生存率
Pulmonary disease,chronic,obstructiveLung tumorLive Combined Bacillus Subtilis and Enterococ-cus Faecium Granules with MultivitaminesDisodium Cantharidinate and Vitamin B6Carcinoembryonic antigenCD3+Toxic and side effectsSurvival rate
《临床误诊误治》 2024 (007)
37-42 / 6
张家口市重点研发计划项目(2322165D)
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