临床误诊误治2024，Vol.37Issue(7)：37-42,6.DOI:10.3969/j.issn.1002-3429.2024.07.008
枯草杆菌二联活菌颗粒联合斑蝥酸钠维生素B6辅助治疗在慢性阻塞性肺疾病合并非小细胞肺癌中的效果研究
摘要
Abstract
Objective To investigate the efficacy of Live Combined Bacillus Subtilis and Enterococcus Faecium Gran-ules with Multivitamines combined with Disodium Cantharidinate and Vitamin B6 in the treatment of chronic obstructive pulmo-nary disease(COPD)complicated with non-small cell lung cancer(NSCLC).Methods A total of 60 patients with COPD combined with NSCLC from January 2020 to October 2022 were selected and divided into the observation group(n=30)and the control group(n=30)by random number table method.Both groups were given chemotherapy combined with immuno-therapy,on the basis of which the control group was given Disodium Cantharidinate and Vitamin B6,and the observation group was given Live Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines Combined with Disodium Cantharidinate and Vitamin B6.Both groups were treated consecutively for 4 cycles.The total response rate after 4 cycles of treatment and the tumor factors[carcinoembryonic antigen(CEA),cancer antigen 125(CA125),vascular endothelial growth factor(VEGF),hypoxia inducible factor-1α(HIF-1α)],immune function indicators(CD3+,CD4+,CD4+/CD8+),and intestinal microecological index(intestinal flora richness and diversity index),toxic and side effects during treatment,and 1-year survival rate after treatment of the two groups before treatment and after 2 and 4 cycles of treatment were analyzed.Results There was no significant difference in the total remission rate between the two groups(P＞0.05).After treatment,CEA,CA125,VEGF and HIF-1α in the two groups decreased,while CD3+,CD4+and CD4+/CD8+increased,with statistical significance(P＜0.05).After treatment,the intestinal flora richness and diversity index of the two groups showed an increasing trend,which were higher in the observation group than in the control group(P＜0.05).The incidence of gas-trointestinal reactions in the observation group was 16.67%(5/30),which was lower than that in the control group(46.67%,14/30)(P＜0.05).There was no significant difference in 1-year survival rate between the two groups(P＞0.05).Conclusion Live Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines Combined with Disodium Cantharidinate and Vitamin B6 can effectively correct the intestinal flora disturbance in COPD patients with NSCLC after chemotherapy and immunotherapy,improve the immune response,inhibit the expression of tumor factors,and reduce the occurrence of toxic and side effects.关键词
肺疾病,慢性,阻塞性/肺肿瘤/枯草杆菌二联活菌颗粒/斑蝥酸钠维生素B6/癌胚抗原/CD3+/毒副反应/生存率Key words
Pulmonary disease,chronic,obstructive/Lung tumor/Live Combined Bacillus Subtilis and Enterococ-cus Faecium Granules with Multivitamines/Disodium Cantharidinate and Vitamin B6/Carcinoembryonic antigen/CD3+/Toxic and side effects/Survival rate分类
临床医学引用本文复制引用
陈俊杰,谢利娜,冀丽佳,田秀丽..枯草杆菌二联活菌颗粒联合斑蝥酸钠维生素B6辅助治疗在慢性阻塞性肺疾病合并非小细胞肺癌中的效果研究[J].临床误诊误治,2024,37(7):37-42,6.基金项目
张家口市重点研发计划项目(2322165D) （2322165D）
