临床误诊误治2024，Vol.37Issue(7)：85-90,6.DOI:10.3969/j.issn.1002-3429.2024.07.016
马应龙麝香痔疮膏对肛周脓肿术后患者症状控制、肛门功能及Col-Ⅰ、TGF-β1、VEGF、EGF水平的影响
Effects of Mayinglong Musk Hemorrhoidal Ointment on Symptom Control,Anal Function and Levels of Col-Ⅰ,TGF-β1,VEGF and EGF in Patients with Perianal Abscess after Operation
摘要
Abstract
Objective To investigate the effects of Mayinglong musk hemorrhoidal ointment on symptom control,anal function and levels of collagen-Ⅰ(COL-Ⅰ),transforming growth factor-β1(TGF-β1),vascular endothelial growth factor(VEGF)and epidermal growth factor(EGF)in patients with perianal abscess after operation.Methods A total of 122 pa-tients undergoing operation for perianal abscess treated from April 2020 to April 2023 were selected and divided into control group(n=61)and observation group(n=61)according to random number table method.The control group was given nor-mal saline debridement,and the observation group was treated with Mayinglong musk hemorrhoidal ointment on the basis of control group.Both groups were treated for 3 weeks and followed up for 6 months.Clinical efficacy at 3 weeks after operation and the occurrence of adverse reactions during treatment were analyzed in the two groups.Symptom control,wound cytokine expression,serum inflammatory factor level and anal function before and at 6 months after operation were compared between the two groups at 1 d and 3 weeks after surgery.Results At 3 weeks after operation,the total effective rate of the observation group[91.80%(56/61)]was higher than that of the control group[78.69%(48/61)](P＜0.05).Wound edema,wound secretion,granulation tissue and pain scores,serum leukocyte interleukin-6(IL-6),interleukin-8(IL-8),tumor nec-rosis factor-α(TNF-α),C reactive protein(CRP)levels at 3 weeks after operation,rectal resting pressure(RRP),resting pressure of anal canal,maximum systolic pressure(MSP)of anal canal and Wexner anal incontinence score at 6 months after operation in the observation group were lower than those in the control group,while the expressions of Col-Ⅰ,TGF-β1,VEGF and EGF in wound tissue were higher than those in control group(P＜0.01).There was no significant difference in the total incidence of adverse reactions between the observation group and the control group[4.92%(3/61)vs 1.64%(1/61)](P＞0.05).Conclusion After the operation for perianal abscess,Mayinglong musk hemorrhoidal ointment can effectively improve the expression level of wound cytokines,reduce the inflammatory response of the body,promote wound healing,help patients to control symptoms,and promote the outcome of anal function,with good therapeutic effect and good safety.关键词
肛周脓肿/马应龙麝香痔疮膏/转化生长因子-β1/血管内皮生长因子/表皮生长因子/直肠静息压/肛管静息压/肛管最大收缩压Key words
Perianal abscess/Mayinglong musk hemorrhoidal ointment/Transforming growth factor-β1/Vascular endothelial growth factor/Epidermal growth factor/Rectal resting pressure/Resting pressure of anal canal/Maximum systolic pressure of anal canal分类
医药卫生引用本文复制引用
曾子荣,陆正明,罗祖平,庞启明..马应龙麝香痔疮膏对肛周脓肿术后患者症状控制、肛门功能及Col-Ⅰ、TGF-β1、VEGF、EGF水平的影响[J].临床误诊误治,2024,37(7):85-90,6.基金项目
海南省自然科学基金高层次人才计划项目(821RC1133) （821RC1133）
