益气化浊利水方联合别嘌醇治疗慢性心力衰竭合并高尿酸血症的临床效果研究OACSTPCD

Objective To investigate the effect of Yiqi Huazhuo Lishui formula combined with Allopurinol in the treatment of chronic heart failure(CHF)complicated with hyperuricemia.Methods A total of 105 patients with CHF and hyperuricemia who were treated from August 2021 to August 2023 were divided into three groups using the random number ta-ble method,with 35 patients in each group.All three groups received conventional treatment,and on this basis,the tradition-al Chinese medicine(TCM)group was treated with Yiqi Huazhuo Lishui formula,the Allopurinol group was treated with Allo-purinol,and the combination group was treated with Yiqi Huazhuo Lishui formula combined with Allopurinol.All groups were treated for 3 months.The clinical efficacy,serum uric acid,left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),thromboxane B2(TXB2),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP),N-terminal pro-brain natriuretic pep-tide(NT-proBNP),6-minute walking distance,nitric oxide(NO),endothelin(ET),calcitonin gene-related peptide(CGRP),and adverse reactions were compared among the three groups.Results The total effective rate of the combination group was94.29%(33/35),which was higher than that of the TCM group(74.29%,26/35)and the Allopurinol group(71.43%,25/35)(P＜0.05),but there was no significant difference between the TCM group and the Allopurinol group(P＞0.05).After treatment,the combination group had lower LVESD,LVEDD,NT-proBNP,hs-CRP,TXB2,TNF-α,ET,and IL-6 than the TCM group and the Allopurinol group,and a longer 6-minute walking distance than the TCM group and the Allopurinol group,and the LVEF,NO,and CGRP were higher than those of the TCM group and the Allopurinol group(P＜0.05);however,there was no significant difference between the TCM group and the Allopurinol group(P＞0.05).After treatment,the serum uric acid level was the lowest in the combination group,followed by the Allopurinol group and the TCM group(P＜0.05).There was no significant difference in the total incidence of adverse reactions among the three groups(P＞0.05).Conclusion The efficacy of the Yiqi Huazhuo Lishui formula combined with Allopurinol in the treatment of CHF pa-tients with hyperuricemia is reliable.It can regulate serum uric acid,inflammatory factors,and NT-proBNP levels,improve vascular endothelial function,promote cardiac function recovery,enhance exercise ability,and is highly safe.