皮肤性病诊疗学杂志2024，Vol.31Issue(5)：340-346,7.DOI:10.3969/j.issn.1674-8468.2024.05.008
皮肤纤维化疾病中肌成纤维细胞来源的研究进展
Research progress in the origins of myofibroblasts in skin fibrotic diseases
摘要
Abstract
Typical skin fibrotic diseases include hypertrophic scar,keloid and scleroderma.These diseases characterized by excessive activation of myofibroblast,and abnormal deposition of extracellular matrix can lead to permanent scarring and organ dysfunction,and seriously affect the physical and mental health of patients.Myofibroblasts play a central role in skin fibrotic diseases.Current studies have shown that fibroblasts,endothelial cells,pericytes,macrophages and other cells can be transformed into myofibroblasts after induction by multiple factors such as pro-fibrotic mediators,activation of signaling pathways related to skin fibrosis,changes in morphological and biochemical characteristics,and expression of myofibroblast markers,including α-smooth muscle actin(α-SMA).Targeting these cell transformation processes is expected to be a new therapeutic strategy for regulating the progression of skin fibrotic disease.Therefore,this review will focus on the progress of the origins of the myofibroblasts in skin fibrotic diseases.关键词
肌成纤维细胞/皮肤纤维化/肌成纤维细胞来源Key words
myofibroblast/skin fibrosis/origins of myofibroblast引用本文复制引用
朱显忠,麦佩君,韦阳海,魏茂云,邱创烨,张沛然,齐庆..皮肤纤维化疾病中肌成纤维细胞来源的研究进展[J].皮肤性病诊疗学杂志,2024,31(5):340-346,7.基金项目
广州市科技计划项目(202201020091) （202201020091）
广东省大学生创新创业项目(S202310570090) （S202310570090）
广州医科大学学生创新能力提升计划项目(02-408-2203-2122) （02-408-2203-2122）
广州医科大学第二临床学院大学生科技创新项目(S2023A013) （S2023A013）
