护理学报2024，Vol.31Issue(10)：1-7,7.DOI:10.16460/j.issn1008-9969.2024.10.001
基于生活方式相关指标的非肥胖人群非酒精性脂肪肝预测模型的构建
Construction of prediction model of non-alcoholic fatty liver disease in non-obese population based on lifestyle-related indicators
欧阳蝶 1许豆豆 2孙燕荣 3陈莹 3吕安康 3吴蓓雯2
作者信息
- 1. 上海交通大学 护理学院,上海 200025
- 2. 上海交通大学医学院附属瑞金医院 护理部,上海 200025
- 3. 上海交通大学医学院附属瑞金医院 体检中心,上海 200025
- 折叠
摘要
Abstract
Objective To construct a prediction model of non-alcoholic fatty liver disease in non-obese population based on lifestyle-related indicators.Methods A prospective cohort study was conducted to select 992 non-obese subjects who participated in physical examination in a tertiary grade-A hospital in Shanghai from April to October 2021 and were followed up until October 2023.The subjects were confirmed whether they had developed non-alcoholic fatty liver disease through abdominal ultrasound during the follow-up and then they were divided into non-occurrence group(n=834)and occurrence group(n=158).General information,results of physical examination and laboratory examination and lifestyle-related indicators were compared between the two groups.LASSO regression and logistic regression were used to analyze the influencing factors and build a prediction model,and a nomogram was drawn.Results Through multi-factor analysis,male(OR=2.375),age(OR=1.044),high income level(OR=0.512),body mass index of 24.0～27.9(OR=3.556),intake of eggs(OR=1.008),vegetable(OR=0.998)and sugar-sweetened beverage(OR=1.002),sitting time(OR=1.199)and sleep time(OR=0.661)were used to construct the prediction model.The area under ROC curve of the model was 0.846,and the area under ROC curve of internal validation was 0.819.The Hosmer-Lemeshow test results of χ2=7.478,P=0.486 indicated good fit.Calibration curve and decision curve analysis showed that the model had good calibration degree and was clinically applicable.Conclusion The prediction model constructed in this study is scientific and practical,with good prediction efficiency,and can easily and effectively predict the risk of non-alcoholic fatty liver disease in non-obese population.关键词
非肥胖/非酒精性脂肪肝/生活方式/预测模型/列线图Key words
non-obese/non-alcoholic fatty liver disease/lifestyle/prediction model/nomogram分类
医药卫生引用本文复制引用
欧阳蝶,许豆豆,孙燕荣,陈莹,吕安康,吴蓓雯..基于生活方式相关指标的非肥胖人群非酒精性脂肪肝预测模型的构建[J].护理学报,2024,31(10):1-7,7.
