南京工业大学学报（自然科学版）2024，Vol.46Issue(3)：272-280,9.DOI:10.3969/j.issn.1671-7627.2024.03.004
虱螨脲中间体连续硝化生产工艺设计与开发
Design and development of continuous nitration production technology of Lufenuron intermediate
摘要
Abstract
In order to study the continuous nitration synthesis process,reactor structure type,reaction temperature,and residence time of 1,4-dichloro-2-(1,1,2,3,3,3-hexafluoropropoxy)-5-nitrobenzene(an intermediate of Lufenuron),a mixed acid composed of concentrated sulfuric acid and nitric acid with a mass ratio of 3∶1 was used as a nitrating agent.A circulating tubular reactor was adopted to study the integrated technology route of reaction and maturation processes.The nitration reaction efficiency was examined at four reaction temperatures of 25 ℃,30 ℃,35 ℃,and 40 ℃ with a maturation temperature at 40 ℃,and the total residence time was calculated.The results showed that the conversion rate of the continuous nitration synthesis process was significantly higher than that of the intermittent nitration process.The controlled reaction temperature increased from the intermittent range of 20 ℃-25 ℃ to 35 ℃,and the reaction time was reduced from 15 hours in the intermittent process to 4 hours.The product yield and quality were also more stable.Additionally,the continuous nitration reaction process was conducive to a quick removal of reaction heat,ensuring reaction safety.关键词
循环管式反应器/1,4-二氯-2-(1,1,2,3,3,3-六氟丙氧基)-5-硝基苯/间歇硝化工艺/连续硝化工艺Key words
circulating tube reactor/1,4-dichloro-2-(1,1,2,3,3,3-hexafluoropropyl)-5-nitrobenzene/intermittent nitrification process/continuous nitrification process分类
化学化工引用本文复制引用
李双涛,魏东旭,黄益平,夏燕喃,黄晶晶,周明杰,何伟,刘辉,沈文彬..虱螨脲中间体连续硝化生产工艺设计与开发[J].南京工业大学学报（自然科学版）,2024,46(3):272-280,9.基金项目
国家自然科学基金面上项目(22178168) （22178168）
江苏省重点研发计划(BE2022791) （BE2022791）
中国建筑集团有限公司2021年科技研发计划(CSCEC-2021-Z-51) （CSCEC-2021-Z-51）
